| Antihypertensive drug combinations: prazosin, hydrochlorothiazide and clonidine. | |
| | |
MedLine Citation:
|
PMID: 356719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fourty-six men and 6 women aged 45 years and having arterial hypertension newly diagnosed at routine medical examinations were given out-patient antihypertensive treatment with prazosin, prazosin + hydrochlorothiazide, or prazosin + hydrochlorothiazide + clonidine. The mean values of blood pressure after the 3-week placebo period were 157/109 mmHg in the supine and 160/115 mmHg in the standing position. Treatment with prazosin (1--2 mg t.i.d.) produced normotension in 4/52 patients only, yet supine diastolic blood pressure and standing blood pressure were significantly lowered within 9 weeks. The addition of hydrochlorothiazide (25 mg daily) for 3 weeks to the regimen led to normotension in 12/46 patients. The remaining 34 patients still having an average supine blood pressure of 152/106 mmHg after prazosin + hydrochlorothiazide, responded well to low doses of clonidine added for 6 weeks to the treatment. Only 7 patients having initially high blood pressure still had a diastolic blood pressure greater than or equal to 100 mmHg at the end of the trial. The subjective side-effects were frequent but mild being roughly similar during placebo and active drug periods, except that fatigue and dry mouth due to clonidine were common, yet tolerable. No "first tablet reactions" to low inital doses of prazosin were found. |
| | |
Authors:
|
T Pitkäjärvi; S Kyöstilä; J Kontro; M J Mattila |
Related Documents
:
|
786689 - Comparison of the antihypertensive effect of propranolol and practolol combined with ch... 10078539 - Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studi... 7599759 - Ace inhibition preserves renal function better than beta-blockade in the treatment of e... 2207419 - Efficacy of potassium and magnesium in essential hypertension: a double-blind, placebo ... 2477339 - The safety and efficacy of terazosin for the treatment of benign prostatic hyperplasia. 8039529 - Statistical evaluation of circadian blood pressure rhythm during isradipine long-term t... 7989899 - Prognosis in therapy-resistant hypertension. 12626969 - Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evo... 3964869 - Artificial sphincter pressure versus detrusor leakage pressure. |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Annals of clinical research Volume: 9 ISSN: 0003-4762 ISO Abbreviation: Ann. Clin. Res. Publication Date: 1977 Oct |
Date Detail:
|
Created Date: 1978-10-27 Completed Date: 1978-10-27 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0220042 Medline TA: Ann Clin Res Country: FINLAND |
Other Details:
|
Languages: eng Pagination: 296-300 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Pressure Determination Clinical Trials as Topic Clonidine / adverse effects, therapeutic use* Drug Combinations Drug Evaluation Female Humans Hydrochlorothiazide / adverse effects, therapeutic use* Hypertension / drug therapy* Male Middle Aged Posture Prazosin / adverse effects, therapeutic use* Quinazolines / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 0/Quinazolines; 19216-56-9/Prazosin; 4205-90-7/Clonidine; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of salbutamol and ephedrine in oral bronchodilator combinations with theophylline and hyd...
Next Document: Effect of calcium p-chlorphenoxyisobutyrate and calcium carbonate on plasma lipids and lipoproteins ...