Document Detail


Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat.
MedLine Citation:
PMID:  14980008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we determined the effects of an extract of Radix Stephaniae Tetrandrae (RST) on arterial blood pressure and heart weight in deoxycorticosterone acetate-salt (DOCA-salt) hypertensive rats. We also determined the effects of the extract on arrhythmia and infarct induced by myocardial ischaemia and reperfusion in anaesthetized rats. We further compared the effects of the extract with those of tetrandrine, which makes up 7% of the extract and is known to act as a calcium-channel antagonist, and verapamil, a prototype calcium-channel antagonist. Treatment with RST extract returned the arterial blood pressure, cardiac compliance and coronary flow towards normal, and reduced right ventricular hypertrophy in the DOCA-salt hypertensive rat. In the anaesthetized rat, the RST extract reduced arrhythmia and infarct size induced by myocardial ischaemia and reperfusion; the effects were similar to those of tetrandrine and verapamil. The findings indicate that the RST extract acts like a calcium-channel antagonist. It may be used in the treatment of cardiovascular diseases, as are the calcium-channel antagonist and tetrandrine. More interestingly, the effects of the RST extract were of the same potency as tetrandrine. Since only 7% of the extract was tetrandrine, the observation indicates that tetrandrine was not the only component that was responsible for the actions of the extract.
Authors:
X-C Yu; S Wu; C-F Chen; K T Pang; T M Wong
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  56     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-24     Completed Date:  2004-06-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / therapeutic use
Animals
Arrhythmias, Cardiac / drug therapy*
Arterial Occlusive Diseases / complications
Benzylisoquinolines / therapeutic use
Calcium Channel Blockers / therapeutic use
Coronary Artery Disease / complications
Drugs, Chinese Herbal / therapeutic use*
Hypertension / drug therapy*
Male
Myocardial Infarction / etiology,  prevention & control
Myocardial Reperfusion Injury / etiology,  prevention & control
Phytotherapy*
Plant Roots
Rats
Rats, Sprague-Dawley
Stephania tetrandra*
Verapamil / therapeutic use
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Benzylisoquinolines; 0/Calcium Channel Blockers; 0/Drugs, Chinese Herbal; 518-34-3/tetrandrine; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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