| Antihypertensive and aldosterone-lowering effects of synthetic atrial natriuretic factor in renin-dependent renovascular hypertension. | |
| | |
MedLine Citation:
|
PMID: 6242558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 24-amino acid residue synthetic atrial natriuretic factor (ANF) antagonizes angiotensin II-induced vascular contractility and aldosterone production in isolated blood vessels and adrenal cells, respectively. To determine the significance of these effects in vivo, the blood pressure and aldosterone responses to synthetic ANF were evaluated in rats with two-kidney, one clip hypertension (n = 5) and in sham-operated controls (n = 4). In the latter, ANF caused a slight fall in mean blood pressure (-7 +/- 3%) and inconsistent changes in plasma renin and aldosterone. In hypertensive rats, ANF decreased blood pressure by 31 +/- 7 mmHg (17 +/- 3%), comparable to the effect of the angiotensin antagonist saralasin (31 +/- 4 mmHg). Plasma renin activity increased from 48 +/- 15 to 79 +/- 23 ng/ml/h. Despite this, ANF caused marked suppression of plasma aldosterone (from 97 +/- 28 to 20 +/- 8.9 ng/100 ml). These results show that ANF can exert potent antihypertensive and aldosterone-lowering effects in vivo, at least when the renin-angiotensin system is stimulated. |
| | |
Authors:
|
M Volpe; G Odell; H D Kleinert; M J Camargot; J H Laragh; J A Lewicki; T Maack; E D Vaughan; S A Atlas |
Related Documents
:
|
17563568 - Increased intima-media thickness of the common carotid artery in primary aldosteronism ... 2293978 - Differential central effects of mineralocorticoid and glucocorticoid agonists and antag... 16024828 - Fluid overload contributing to heart failure. 10338428 - Posttraumatic hypertension secondary to adrenal hemorrhage mimicking pheochromocytoma: ... 11823088 - Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients re... 8466118 - Intrinsic positive end-expiratory pressure in ambulatory patients with airways obstruct... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 2 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1984 Dec |
Date Detail:
|
Created Date: 1986-06-25 Completed Date: 1986-06-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: S313-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
blood Aldosterone Antagonists* Animals Antihypertensive Agents* Atrial Natriuretic Factor / therapeutic use* Blood Pressure / drug effects Drug Evaluation, Preclinical Hypertension, Renovascular / blood, drug therapy* Male Rats Rats, Inbred Strains Renin / blood* Saralasin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
HL-00570/HL/NHLBI NIH HHS; HL-18323-SCR/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Aldosterone Antagonists; 0/Antihypertensive Agents; 34273-10-4/Saralasin; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Atriopeptins: bioactive peptides derived from mammalian cardiac atria.
Next Document: Atrial natriuretic factor: purification of active peptides, cloning of cDNA and determination of str...