Document Detail

Antihypertensive agents for aging patients who are at risk for cognitive dysfunction.
MedLine Citation:
PMID:  16386204     Owner:  NLM     Status:  MEDLINE    
Observational and experimental data continue to accumulate about the impact of blood pressure (BP) and antihypertensive agents on cognitive function. Current evidence suggests that there is a U-shaped association between BP earlier in life and poor cognitive function and clinical dementia, including Alzheimer's disease. This association has been identified more consistently in longitudinal surveys due to the fact that BP declines when cognitive symptoms start. Lowering BP provides protection against this complication of high BP. This effect is present in the cognitively intact and in those with dementia. Antihypertensives that cross the blood brain barrier and affect the renin-angiotensin-aldosterone system (such as perindopril or losartan) or brain calcium metabolism (nitrendipine) provide additional protection beyond BP control against cognitive decline. These drugs may be preferred in such clinical situations.
Ihab Hajjar; Michelle Keown; Brandy Frost
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  7     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-02     Completed Date:  2006-05-04     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-73     Citation Subset:  IM    
Department of Internal Medicine, Palmetto Health Richland/University of South Carolina, 9 Medical Park Drive, Suite 230, Columbia, SC 29203, USA.
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MeSH Terms
Age Factors
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects,  physiology
Cognition Disorders / complications*
Hypertension / complications,  drug therapy*,  physiopathology
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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