| Antihypertensive activity of verapamil: impact of dietary sodium. The VERSAL Study Group. | |
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MedLine Citation:
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PMID: 8397246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To define the influence of dietary salt intake on the antihypertensive effect of slow-release verapamil 240 mg once a day in a population with mild-to-moderate essential hypertension. DESIGN: Parallel, randomized, multicentre study. METHODS: Patients were advised to follow a moderately low salt diet (Low-salt group). After a 2-week run-in period, those patients with 24-h urinary sodium excretion (UNa) < or = 120 mmol/day and a diastolic blood pressure (DBP) between 90 and 114 mmHg were randomly assigned to verapamil + Low-salt or verapamil + unrestricted-salt diet (High-salt group) for 28 days. Compliance with diets was defined as Low-salt UNa < or = 120 mmol/day and High-salt UNa > 120 mmol/day with UNa increased by > or = 60 mmol/day over the level attained at the end of the run-in period. RESULTS: Significant reductions in mean systolic blood pressure (SBP) and DBP were found in both the Low-salt (n = 235) and High-salt (n = 183) groups. The therapeutic goal (DBP < 90 mmHg) was achieved in 38.3% of patients in the Low-salt and 44.8% of patients in the High-salt group. Office blood pressure results were confirmed by ambulatory 24-h blood pressure monitoring in a subsample of patients. Verapamil reduced mean blood pressure throughout the nycthemeral cycle without any significant difference between the two groups. CONCLUSION: The restriction in sodium intake does not have an additive effect on the antihypertensive effect of the slow-channel calcium antagonist verapamil. |
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Authors:
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J Redón-Más; J Abellán-Alemán; P Aranda-Lara; M de la Figuera-von Wichmann; M Luque-Otero; J L Rodicio-Díaz; L M Ruilope-Urioste; J Velasco-Quintana |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of hypertension Volume: 11 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-10-20 Completed Date: 1993-10-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 665-71 Citation Subset: IM |
Affiliation:
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Hospital de Sagunto, Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects Diet, Sodium-Restricted* Female Humans Hypertension / drug therapy* Male Middle Aged Verapamil / adverse effects, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 52-53-9/Verapamil |
| Comments/Corrections | |
Erratum In:
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J Hypertens 1994 Apr;12(4):following H14 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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