Document Detail

Antihypertensive activity of verapamil: impact of dietary sodium. The VERSAL Study Group.
MedLine Citation:
PMID:  8397246     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To define the influence of dietary salt intake on the antihypertensive effect of slow-release verapamil 240 mg once a day in a population with mild-to-moderate essential hypertension. DESIGN: Parallel, randomized, multicentre study. METHODS: Patients were advised to follow a moderately low salt diet (Low-salt group). After a 2-week run-in period, those patients with 24-h urinary sodium excretion (UNa) < or = 120 mmol/day and a diastolic blood pressure (DBP) between 90 and 114 mmHg were randomly assigned to verapamil + Low-salt or verapamil + unrestricted-salt diet (High-salt group) for 28 days. Compliance with diets was defined as Low-salt UNa < or = 120 mmol/day and High-salt UNa > 120 mmol/day with UNa increased by > or = 60 mmol/day over the level attained at the end of the run-in period. RESULTS: Significant reductions in mean systolic blood pressure (SBP) and DBP were found in both the Low-salt (n = 235) and High-salt (n = 183) groups. The therapeutic goal (DBP < 90 mmHg) was achieved in 38.3% of patients in the Low-salt and 44.8% of patients in the High-salt group. Office blood pressure results were confirmed by ambulatory 24-h blood pressure monitoring in a subsample of patients. Verapamil reduced mean blood pressure throughout the nycthemeral cycle without any significant difference between the two groups. CONCLUSION: The restriction in sodium intake does not have an additive effect on the antihypertensive effect of the slow-channel calcium antagonist verapamil.
J Redón-Más; J Abellán-Alemán; P Aranda-Lara; M de la Figuera-von Wichmann; M Luque-Otero; J L Rodicio-Díaz; L M Ruilope-Urioste; J Velasco-Quintana
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  11     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-20     Completed Date:  1993-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  665-71     Citation Subset:  IM    
Hospital de Sagunto, Valencia, Spain.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Diet, Sodium-Restricted*
Hypertension / drug therapy*
Middle Aged
Verapamil / adverse effects,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 52-53-9/Verapamil
Erratum In:
J Hypertens 1994 Apr;12(4):following H14

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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