Document Detail


Antihypertensive activity of verapamil: impact of dietary sodium. The VERSAL Study Group.
MedLine Citation:
PMID:  8397246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To define the influence of dietary salt intake on the antihypertensive effect of slow-release verapamil 240 mg once a day in a population with mild-to-moderate essential hypertension. DESIGN: Parallel, randomized, multicentre study. METHODS: Patients were advised to follow a moderately low salt diet (Low-salt group). After a 2-week run-in period, those patients with 24-h urinary sodium excretion (UNa) < or = 120 mmol/day and a diastolic blood pressure (DBP) between 90 and 114 mmHg were randomly assigned to verapamil + Low-salt or verapamil + unrestricted-salt diet (High-salt group) for 28 days. Compliance with diets was defined as Low-salt UNa < or = 120 mmol/day and High-salt UNa > 120 mmol/day with UNa increased by > or = 60 mmol/day over the level attained at the end of the run-in period. RESULTS: Significant reductions in mean systolic blood pressure (SBP) and DBP were found in both the Low-salt (n = 235) and High-salt (n = 183) groups. The therapeutic goal (DBP < 90 mmHg) was achieved in 38.3% of patients in the Low-salt and 44.8% of patients in the High-salt group. Office blood pressure results were confirmed by ambulatory 24-h blood pressure monitoring in a subsample of patients. Verapamil reduced mean blood pressure throughout the nycthemeral cycle without any significant difference between the two groups. CONCLUSION: The restriction in sodium intake does not have an additive effect on the antihypertensive effect of the slow-channel calcium antagonist verapamil.
Authors:
J Redón-Más; J Abellán-Alemán; P Aranda-Lara; M de la Figuera-von Wichmann; M Luque-Otero; J L Rodicio-Díaz; L M Ruilope-Urioste; J Velasco-Quintana
Related Documents :
9039146 - Effect of high salt intake in mutant mice lacking bradykinin-b2 receptors.
10981546 - Nitric oxide and salt sensitivity.
2514656 - Role of kinins and prostacyclin in blood pressure regulation.
12619866 - Increased salt sensitivity secondary to leptin resistance in shhf rats is mediated by e...
16213606 - Cardiac effects of oxytocin: is there a role for this peptide in cardiovascular homeost...
429516 - Increased ratio between changes in blood pressure and plasma norepinephrine in essentia...
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  11     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-20     Completed Date:  1993-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  665-71     Citation Subset:  IM    
Affiliation:
Hospital de Sagunto, Valencia, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Diet, Sodium-Restricted*
Female
Humans
Hypertension / drug therapy*
Male
Middle Aged
Verapamil / adverse effects,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 52-53-9/Verapamil
Comments/Corrections
Erratum In:
J Hypertens 1994 Apr;12(4):following H14

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of moderate sodium restriction on clinic and twenty-four-hour ambulatory blood pressure in e...
Next Document:  Comparative accuracy of six ambulatory devices according to blood pressure levels.