Document Detail

Antihypertensive activity of indolepyruvic acid: a keto analogue of tryptophan.
MedLine Citation:
PMID:  1688965     Owner:  NLM     Status:  MEDLINE    
We studied the effect of indole-3-pyruvic acid (IPA) on systolic blood pressure of normotensive, spontaneously hypertensive, DOCA + salt hypertensive, and Grollman hypertensive rats. Experiments were also carried out in order to investigate whether IPA may influence the development of hypertension in spontaneously hypertensive rats. Age-matched normotensive, spontaneously hypertensive, DOCA + salt hypertensive, and Grollman hypertensive rats treated with N-methylglucamine, were used as controls. Acute oral (up to 50 mg/kg) and intravenous (5 mg/kg) administration of IPA did not change systolic blood pressure in any models of hypertension. By contrast, a repeated administration of IPA (100 mg/kg/day, by oral gavage for 10 days) significantly decreased systolic blood pressure in all models of hypertension, while it elicited no significant effect in normotensive rats. Moreover, when IPA was given daily to 5-week-old spontaneously hypertensive rats for 7 weeks, it partially inhibited the development of hypertension. In addition, chronic administration of IPA caused enhanced levels of tryptophan and 5-hydroxyindoleacetic acid in the cortex and diencephalon. Brainstem serotonin content in both normotensive and spontaneously hypertensive rats was also enhanced by IPA treatment. Our results suggest that IPA lowers blood pressure in different rat models of hypertension and this effect seems to be correlated with an increase in cerebral serotonin metabolism.
F Squadrito; R Sturniolo; G R Trimarchi; G M Campo; G De Luca; A Gorini; A P Caputi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  15     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-27     Completed Date:  1990-02-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  IM    
Institute of Pharmacology, School of Medicine, University of Messina, Italy.
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MeSH Terms
Antihypertensive Agents*
Blood Pressure / drug effects
Brain Chemistry / drug effects
Hypertension / chemically induced,  physiopathology
Hypertension, Renovascular / physiopathology
Indoles / pharmacology*
Meglumine / pharmacology
Rats, Inbred Strains
Rats, Inbred WKY
Tryptophan / analogs & derivatives*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Indoles; 392-12-1/indol-3-yl pyruvic acid; 6284-40-8/Meglumine; 64-85-7/Desoxycorticosterone; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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