| Antihypertensive action of bromocriptine in neurogenic hypertensive dogs. | |
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MedLine Citation:
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PMID: 7305559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of bromocriptine, a dopamine agonist, were studied on blood pressure and heart rate in neurogenic hypertensive (sino-aortic denervated) anaesthetized dogs. Bromocriptine induced a very marked decrease in blood pressure but failed to modify the values of heart rate under our experimental conditions. This anti-hypertensive action of bromocriptine was abolished by pretreatment with dopamine antagonists: haloperidol, sulpiride or metoclopramide. Bilateral nephrectomy or ligature of both renal and mesenteric arteries (i.e. exclusion of the two major beds with postsynaptic dopaminergic receptors) failed to suppress the decrease in blood pressure elicited by bromocriptine in neurogenic hypertensive dogs. These results suggest that the antihypertensive action of bromocriptine in neurogenic hypertensive dogs was mainly due to an action on presynaptic and/or ganglionic peripheral dopaminergic receptors located on sympathetic nerve endings. The potential future importance of dopaminergic agonists as antihypertensive drugs is discussed. |
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Authors:
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J L Montastruc; P Montastruc |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 252 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1982-01-20 Completed Date: 1982-01-20 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 210-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents* Blood Pressure / drug effects Bromocriptine / pharmacology* Dogs Female Heart Rate / drug effects Hypertension / drug therapy* Male Mesenteric Arteries / drug effects Nephrectomy Renal Artery / drug effects Time Factors Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 25614-03-3/Bromocriptine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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