Document Detail


Antihypertensive action of bromocriptine in neurogenic hypertensive dogs.
MedLine Citation:
PMID:  7305559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of bromocriptine, a dopamine agonist, were studied on blood pressure and heart rate in neurogenic hypertensive (sino-aortic denervated) anaesthetized dogs. Bromocriptine induced a very marked decrease in blood pressure but failed to modify the values of heart rate under our experimental conditions. This anti-hypertensive action of bromocriptine was abolished by pretreatment with dopamine antagonists: haloperidol, sulpiride or metoclopramide. Bilateral nephrectomy or ligature of both renal and mesenteric arteries (i.e. exclusion of the two major beds with postsynaptic dopaminergic receptors) failed to suppress the decrease in blood pressure elicited by bromocriptine in neurogenic hypertensive dogs. These results suggest that the antihypertensive action of bromocriptine in neurogenic hypertensive dogs was mainly due to an action on presynaptic and/or ganglionic peripheral dopaminergic receptors located on sympathetic nerve endings. The potential future importance of dopaminergic agonists as antihypertensive drugs is discussed.
Authors:
J L Montastruc; P Montastruc
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  252     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents*
Blood Pressure / drug effects
Bromocriptine / pharmacology*
Dogs
Female
Heart Rate / drug effects
Hypertension / drug therapy*
Male
Mesenteric Arteries / drug effects
Nephrectomy
Renal Artery / drug effects
Time Factors
Vagotomy
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 25614-03-3/Bromocriptine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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