Document Detail


Antihypertensive effect of Benifuuki tea containing O-methylated EGCG.
MedLine Citation:
PMID:  20078079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Benifuuki is a tea cultivar with an antiallergic effect stronger than that of Yabukita tea, the most popular green tea cultivar consumed in Japan. The effective compound is (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3''Me), an O-methylated derivative of EGCG. This study examined the antihypertensive effects of EGCG3''Me and Benifuuki tea. First, it was determined that EGCG3''Me has a significant inhibitory effect on the activity of angiotensin I-converting enzyme (ACE). Second, clinical trials showed that Benifuuki tea suppressed high blood pressure to a greater extent than green tea that did not contain EGCG3''Me after equal amounts of tea catechins were consumed for 8 weeks. The effect of Benifuuki tea on human hypertension is mainly the result of the strong inhibitory effect of EGCG3''Me on ACE activity, its high rate of absorption, and its stability in the blood.
Authors:
Ikuko Kurita; Mari Maeda-Yamamoto; Hirofumi Tachibana; Masanori Kamei
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1903-8     Citation Subset:  IM    
Affiliation:
Morinaga & Company, Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. i-kurita-jb@morinaga.co.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents / administration & dosage*,  chemistry
Blood Pressure / drug effects
Camellia sinensis / chemistry*
Catechin / administration & dosage,  analogs & derivatives*,  chemistry
Double-Blind Method
Female
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Peptidyl-Dipeptidase A / metabolism
Plant Extracts / administration & dosage*,  chemistry
Tea / chemistry
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Plant Extracts; 0/Tea; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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