| Antihypertensive effect of Benifuuki tea containing O-methylated EGCG. | |
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MedLine Citation:
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PMID: 20078079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Benifuuki is a tea cultivar with an antiallergic effect stronger than that of Yabukita tea, the most popular green tea cultivar consumed in Japan. The effective compound is (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3''Me), an O-methylated derivative of EGCG. This study examined the antihypertensive effects of EGCG3''Me and Benifuuki tea. First, it was determined that EGCG3''Me has a significant inhibitory effect on the activity of angiotensin I-converting enzyme (ACE). Second, clinical trials showed that Benifuuki tea suppressed high blood pressure to a greater extent than green tea that did not contain EGCG3''Me after equal amounts of tea catechins were consumed for 8 weeks. The effect of Benifuuki tea on human hypertension is mainly the result of the strong inhibitory effect of EGCG3''Me on ACE activity, its high rate of absorption, and its stability in the blood. |
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Authors:
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Ikuko Kurita; Mari Maeda-Yamamoto; Hirofumi Tachibana; Masanori Kamei |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1903-8 Citation Subset: IM |
Affiliation:
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Morinaga & Company, Ltd., 2-1-1 Shimosueyoshi, Tsurumi-ku, Yokohama 230-8504, Japan. i-kurita-jb@morinaga.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents / administration & dosage*, chemistry Blood Pressure / drug effects Camellia sinensis / chemistry* Catechin / administration & dosage, analogs & derivatives*, chemistry Double-Blind Method Female Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Peptidyl-Dipeptidase A / metabolism Plant Extracts / administration & dosage*, chemistry Tea / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Plant Extracts; 0/Tea; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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