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Antihyperlipidemic potential of Cedrus deodara extracts in monosodium glutamate induced obesity in neonatal rats.
MedLine Citation:
PMID:  22144766     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the antihyperlipidemic effect of Cedrus deodara (C. deodara) against monosodium glutamate (MSG) induced obesity in neonatal rats.
MATERIALS AND METHODS: The studies were carried out on newborn neonatal rats and were injected intraperitoneally with 2 mg/g of MSG on the 2(nd) and 4(th) postnatal days and 4 mg/g on 6(th), 8(th) and 10(th) postnatal days. Ethanolic extract (EE) and acetone extract (AE) of C. deodara was administered in a dose of 100 and 200 mg/kg, p.o./day at the age of 65 days. On day 60 of treatment, body weight, locomotor activity, body temperature, and various biochemical parameters like serum glucose, total cholesterol, triglyceride, and organs weights were recorded.
RESULTS: There was a significant reduction in body weight, organs and increased body temperature, locomotor activity after treatment with extracts. C. deodara decreased serum glucose, total cholesterol and triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels and increased high density lipoprotein (HDL) significantly has compared to MSG-control rats.
CONCLUSION: C. deodara extracts exhibited antihyperlipidemic effect and it possesses anti-obesity properties in MSG induced obese rats.
Authors:
Sudhir Patil; T Prakash; D Kotresha; N Rama Rao; Naitik Pandy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pharmacology     Volume:  43     ISSN:  1998-3751     ISO Abbreviation:  Indian J Pharmacol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-06     Completed Date:  2012-09-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7902477     Medline TA:  Indian J Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  -    
Affiliation:
Department of Pharmacology, Acharya and B.M. Reddy College of Pharmacy, Bangalore-560 090, India.
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