| Antihyperlipidemic effect of the methanolic extract from Lagenaria siceraria Stand. fruit in hyperlipidemic rats. | |
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MedLine Citation:
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PMID: 19397976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ETHNOPHARMACOLOGICAL RELEVANCE: Lagenaria siceraria Stand. (Cucurbitaceae) fruits have been used, traditionally, in the treatment of hyperlipidemia and atherosclerotic impasse and considered as cardioprotective and cardiotonic drug. AIM OF THE STUDY: The present work was undertaken to investigate the effects of methanolic extract from Lagenaria siceraria in experimentally induced hyperlipidemia in rats. MATERIALS AND METHODS: Methanolic extract of Lagenaria siceraria fruits (LSFE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10mg/kg; p.o.) was used as a standard drug. RESULTS: At the 30 th day, most significant reduction in lipid levels in the LSFE treated rats as compared to the rats fed with high-fat diet at the 0th day were: total cholesterol 290.14+/-18.42 mg/dl vs. 228.58+/-16.38 mg/dl, low-density lipoprotein cholesterol 195.14+/-8.86 mg/dl vs. 120.57+/-8.11 mg/dl, triglyceride 232.41+/-15.22 mg/dl vs. 181.79+/-15.68 mg/dl, very low-density lipoprotein cholesterol 46.48+/-3.04 mg/dl vs. 36.35+/-3.13 mg/dl (P<0.0001). Conversely, high-density lipoprotein cholesterol levels were significantly (P<0.0001) increased from 48.52+/-6.52 to 71.66+/-5.14 mg/dl. The increase in weight in rats administered with LSFE was less when compared to rats fed with high-fat diet. Moreover, LSFE also exhibited significant increase in excretion of bile acids. CONCLUSION: The results demonstrate that the LSFE has a definite antihyperlipidemic potential. There is also a valid scientific basis for consuming it in the treatment of coronary artery diseases in India. |
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Authors:
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B V Ghule; M H Ghante; A N Saoji; P G Yeole |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-03 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 124 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Institute of Pharmaceutical Education and Research, Department of Pharmacognosy and Phytochemistry, Borgaon (Meghe), Wardha, Maharashtra 442 001, India. ghulebv@rediffmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology, therapeutic use Antilipemic Agents / pharmacology, therapeutic use* Bile Acids and Salts / metabolism Cholesterol / blood* Cucurbitaceae* Dietary Fats Disease Models, Animal Feces / chemistry Fruit Heptanoic Acids / pharmacology, therapeutic use Hyperlipidemias / blood, drug therapy* Male Phytotherapy* Plant Extracts / pharmacology, therapeutic use* Pyrroles / pharmacology, therapeutic use Rats Rats, Wistar Triglycerides / blood* Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Antilipemic Agents; 0/Bile Acids and Salts; 0/Dietary Fats; 0/Heptanoic Acids; 0/Plant Extracts; 0/Pyrroles; 0/Triglycerides; 110862-48-1/atorvastatin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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