| Antihyperlipidemic activity of Clitoria ternatea and Vigna mungo in rats. | |
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MedLine Citation:
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PMID: 20673179 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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CONTEXT: Hyperlipidemia is one of the major risk factors for atherosclerosis and cardiovascular diseases. Some plants are effective in controlling hyperlipidemia. OBJECTIVE: To investigate the anti-hyperlipidemic effect of Clitoria ternatea L. and Vigna mungo L. (Fabaceae) on experimentally induced hyperlipidemia in rats. MATERIALS AND METHODS: The poloxamer 407-induced acute hyperlipidemia and diet-induced hyperlipidemia models were used for this investigation. RESULTS: Oral administration of the hydroalcoholic extract of the roots and seeds of C. ternatea and the hydroalcoholic extract of the seeds of V. mungo resulted in a significant (p < 0.05) reduction of serum total cholesterol, triglycerides, very low-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels. The atherogenic index and the HDL/LDL ratio were also normalized after treatment in diet-induced hyperlipidemic rats. The effects were compared with atorvastatin (50 mg/kg, p.o.) and gemfibrozil (50 mg/kg, p.o.), reference standards. DISCUSSION: The cholesterol-lowering effect of C. ternatea might be attributed to increased biliary excretion and decreased absorption of dietary cholesterol. The cholesterol-lowering effects of V. mungo seeds might be because of decreased HMG-CoA reductase activity, increased biliary excretion, and decreased absorption of dietary cholesterol. Additionally, they improved natural antioxidant defense mechanisms. CONCLUSION: The findings of the investigation suggest that C. ternatea and V. mungo have significant antihyperlipidemic action against experimentally-induced hyperlipidemia. |
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Authors:
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Yogendrasinh B Solanki; Sunita M Jain |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmaceutical biology Volume: 48 ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: England |
Other Details:
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Languages: eng Pagination: 915-23 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, India. dy_solanki@yahoo.co.in |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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