| Antihyperglycemic, antihyperlipidemic and antioxidant activities of traditional aqueous extract of Zygophyllum album in streptozotocin diabetic mice. | |
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MedLine Citation:
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PMID: 22209473 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: The aim of this work was to investigate the antihyperglycemic, antioxidant and antihyperlipidemic effects of the aqueous extract of Zygophyllum album on streptozotocin (STZ)-induced diabetic mice. Methods: Diabetes was induced in Swiss albino mice by the administration of STZ (45mg/kg b.w.) intraperitoneally. Aqueous extract of Z. album (100 and 300mg/kg b.w.) was administered by oral gavage once a day for a period of 15days. The effect of the extract on blood glucose, lipids, cholesterol levels in plasma, and also on enzymatic and non enzymatic antioxidants of defence systems such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme activities, and vitamin C, vitamin E and glutathione reductase (GSH) levels in liver and pancreas were studied. Results: Our results showed that Z. album extract reduced the blood glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) levels in STZ-diabetic mice. It also significantly abolished the increase in MDA level, and GPx, SOD and CAT activities in both liver and pancreas. The levels of GSH, vitamin C and high-density lipoprotein (HDL) were significantly augmented in Z. album treated diabetic mice in comparison with control group. Our findings suggest that Z. album aqueous extract prevented the diabetic induced MDA levels via the enhancement of the tissue GSH and blood vitamin C levels. Conclusions: These results suggest that Z. album extract exerts the anti-diabetic and antihypercholesterolemic activities through its antioxidant properties. |
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Authors:
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Jamel El Ghoul; Moêz Smiri; Saad Ghrab; Naceur A Boughattas; Mossadok Ben-Attia |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Pathophysiology : the official journal of the International Society for Pathophysiology / ISP Volume: - ISSN: 0928-4680 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433813 Medline TA: Pathophysiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Unité de Toxicométrie & Chronobiométrie, Laboratoire de Biosurveillance de l'Environnement (LR01/ES14), Faculté des Sciences de Bizerte, Université de Carthage, 7021 Zarzouna, Tunisia; Département des Sciences de la Vie, Faculté des Sciences de Bizerte, Université de Carthage, 7021 Zarzouna, Tunisia. |
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