| Antihyperglycemic Effect of Syringaldehyde in Streptozotocin-Induced Diabetic Rats. | |
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MedLine Citation:
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PMID: 22880723 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats. |
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Authors:
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Chia-Hsin Huang; Mei-Fen Chen; Hsien-Hui Chung; Juei-Tang Cheng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-10 |
Journal Detail:
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Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Agricultural Research Institute, Council of Agriculture Executive , Taichung, Taiwan 40512. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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