Document Detail


Antihistamines in late-phase clinical development for allergic disease.
MedLine Citation:
PMID:  11829715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Allergic rhinitis (AR) is a global health concern and shares a high comorbidity with asthma. Recent research suggests that different allergic diseases, such as AR, asthma, allergic conjunctivitis and chronic idiopathic urticaria (CIU), are evoked by common pathological mechanisms characterised by the release of histamine and other inflammatory mediators. Although H(1) receptor antagonists are the mainstay of therapy for allergic disease, the unacceptably high incidence of anticholinergic and CNS-related side effects of first-generation H(1) antagonists led to the search for improved second-generation H(1) antagonists. While many of these agents were largely devoid of CNS side effects, their tendency for drug-drug interactions (e.g., terfenadine and astemizole) resulted in an increased incidence of cardiotoxicity. Furthermore, second-generation H(1) antagonists exhibited weak anti-inflammatory properties and had no effect on nasal congestion. These observations emphasised the need for newer anti-allergic agents with a broader spectrum of activity and an improved safety profile. Among the newer H(1) antagonists currently in clinical development, desloratadine and mizolastine are the most widely studied. Both have a rapid onset of action, and desloratadine has demonstrated clinical efficacy in AR, CIU and seasonal asthma. Desloratadine has several advantages over other H(1) antagonists in that it has proven decongestant activity, a sparing effect on the use of bronchodilators (beta(2)-agonists) and a low potential for drug interactions. The broad anti-inflammatory properties of desloratadine and mizolastine, which distinguish these agents from other H(1) antagonists in clinical development (e.g., norastemizole and levocetirizine), suggest they may have a more profound impact on the underlying disease in patients suffering from different forms of allergy. The lack of clinical efficacy and safety data on rupatadine and HSR-609, both novel H(1) antagonists, precludes an accurate assessment of their potential for treating allergic disease. Epinastine and efletirizine are being developed exclusively for topical application and are unlikely to play a significant role in the management of allergic diseases as a whole.
Authors:
Luis M Salmun
Related Documents :
10386495 - Gastric asthma: an unrecognized disease with an unsuspected frequency.
11450335 - Environmental pollutants and allergy diseases.
14726635 - Do mouse models of allergic asthma mimic clinical disease?
2556545 - Treatment of hay fever.
21124085 - Update on antiglomerular basement membrane disease.
23150265 - Epigenetics in parkinson's and alzheimer's diseases.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  11     ISSN:  1354-3784     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-06     Completed Date:  2003-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-73     Citation Subset:  IM    
Affiliation:
Schering-Plough Research Institute, 2000 Galloping Hill Rd., Building K-5, 2nd Floor, Mailstop B-2, Kenilworth, NJ 07033, USA. luis.salmun@spcorp.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  pharmacology,  therapeutic use
Asthma / drug therapy
Chronic Disease
Clinical Trials as Topic
Conjunctivitis, Allergic / drug therapy
Histamine H1 Antagonists / adverse effects,  pharmacology,  therapeutic use*
Humans
Hypersensitivity / drug therapy*,  immunology
Rhinitis, Allergic, Perennial / drug therapy,  immunology
Urticaria / drug therapy
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Histamine H1 Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fluoroquinolones and tuberculosis.
Next Document:  Therapeutic potential of thromboxane inhibitors in asthma.