Document Detail

Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.
MedLine Citation:
PMID:  20465620     Owner:  NLM     Status:  MEDLINE    
Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.
Alexander A Navarini; Marcel Stoeckle; Susanne Navarini; Erik Mossdorf; Boniphace S Jullu; Rehema Mchomvu; Marco Mbata; Patience Kibatala; Marcel Tanner; Christoph Hatz; Peter Schmid-Grendelmeier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  49     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Ifakara Health Institute, Ifakara, Kilombero, Tanzania.
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MeSH Terms
Administration, Oral
Administration, Topical
Antiretroviral Therapy, Highly Active
CD4-CD8 Ratio
Exanthema / drug therapy*,  pathology,  virology
HIV Infections / complications*,  drug therapy,  immunology
Histamine Antagonists / administration & dosage*
Histamine H1 Antagonists / administration & dosage
Promethazine / administration & dosage
Pruritus / drug therapy*,  pathology,  virology
Retrospective Studies
Steroids / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Histamine Antagonists; 0/Histamine H1 Antagonists; 0/Steroids; 60-87-7/Promethazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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