| Antihepatoma Activity of the Acid and Neutral Components from Ganoderma lucidum. | |
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MedLine Citation:
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PMID: 22275242 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ganoderma lucidum extracts or isolated components have been shown previously to acquire many potential biochemical and pharmacological activities, including cancer preventive or antitumor effects. The supercritical fluid extracts of Ganoderma lucidum (total component, TC) and its acid component (AC) and neutral component (NC), were evaluated in vitro and in vivo for their antihepatoma activities. The NC showed a conspicuous inhibitory effect on tumor growth of Heps-bearing mice, whereas AC was less effective. The TC, NC and AC all inhibited the proliferation of BEL-7402 cells through apoptosis pathway and cell cycle arrest. Additionally, the NC and TC induced cell cycle arrest at the G2/M phase, but the AC resulted in a marked increase in the percentage of cells at G1 phase by flow cytometry. It is suggested that NC is an indispensable effective component in terms of antihepatoma activity and its constituents need to be investigated in detail. It was found that the NC, which was detected by GC-MS, contained fatty acids and steroids; hence, it is proposed that some compounds such as long-chain fatty acids and steroids in the NC might also contribute to the antihepatoma activity, although the anticancer activities of G. lucidum traditionally have been considered to be associated with triterpenoids. Copyright © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Hui Lu; Jie Song; Xiao-Bin Jia; Liang Feng |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: - ISSN: 1099-1573 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Key Laboratory of Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, 210028, PR China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210046, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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