| Antiglaucoma medications during pregnancy and the risk of low birth weight: a population-based study. | |
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MedLine Citation:
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PMID: 19520696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the relationship between using antiglaucoma medications during pregnancy and the risk of having low-birth-weight (LBW) infants. METHODS: The study group comprised 244 pregnant women who had been prescribed topical medication to control glaucoma during pregnancy. The comparison group comprised 1952 pregnant women matched for age, year of delivery, maternal hypertension and gestational diabetes. Multivariate logistic regressions were conducted to calculate the adjusted odds ratio of having LBW infants. RESULTS: The majority of pregnant women (77.5%) were prescribed beta-blockers to control glaucoma. After adjusting for characteristics of the infant (gender, parity and gestational age), mother (age, the highest educational level, marital status, hypertension and gestational diabetes), father (the highest educational level), parental age difference and family monthly income, there was no significant difference in the risk of LBW infants between mothers prescribed beta-blockers and mothers in the comparison cohort (adjusted odds ratio (OR) 1.48, 95% CI 0.86 to 2.56). However, there was a significantly higher risk of LBW infants for mothers prescribed topical antiglaucoma medications other than beta-blockers (adjusted OR 2.15, 95% CI 1.05 to 5.00). CONCLUSIONS: Topical beta-blockers can be the first-line drugs when considering medical treatment of glaucoma in a pregnant woman. |
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Authors:
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J-D Ho; C-C Hu; H-C Lin |
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Publication Detail:
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Type: Journal Article Date: 2009-06-10 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 93 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-25 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 1283-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Taipei Medical University Hospital, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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adverse effects Adult Antihypertensive Agents / adverse effects* Birth Weight / drug effects Cohort Studies Female Fetal Development / drug effects Glaucoma / drug therapy* Humans Infant, Low Birth Weight* Infant, Newborn Male Maternal-Fetal Exchange Pregnancy Pregnancy Complications / drug therapy* Risk Factors Socioeconomic Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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