| Antigenicity of venous allografts. | |
| | |
MedLine Citation:
|
PMID: 106782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
With isolated exceptions, the clinical use of venous allografts has been disappointing. Considerable evidence indicates that allograft antigenicity plays a major role in the failure of venous allografts when used as arterial replacements. Recent reports suggest that DMSO-cryopreservation of venous allografts may reduce allograft antigenicity while preserving allograft viability. The present study examines the effect of modifications of vein allografts on subsequent allograft antigenicity. Skin grafts were transplanted from ACI to Lewis inbred strains of male rats. Primary skin graft rejection occurred in 9.0 +/- 1.0 days. Subcutaneous implantation of fresh inferior vena cava from ACI rate into Lewis rats resulted in subsequent skin graft rejection in 5.0 +/- 1.0 days, confirming the antigenicity of venous tissue. Cryopreservation of ACI inferior vena cava for seven days prior to implantation, with or without 15% DMSO, resulted in subsequent skin graft rejection in 5.0 +/- 1.0 days. Treatment of ACI inferior vena cava with 0.30% gluteraldehyde for 20 minutes prior to implantation in Lewis rats resulted in skin graft rejection in 9.0 +/- 1.0 days, the same time as a first set rejection. This study indicates that unmodified veins are normally antigenic and that this antigenicity is not eliminated by cryopreservation with or without DMSO. Gluteraldehyde treatment appears to reduce allograft antigenicity, but results in a nonviable graft. At the present time, there is no known way to reduce the antigenicity of viable venous allografts. |
| | |
Authors:
|
S C Axthelm; J M Porter; S Strickland; G M Baur |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Annals of surgery Volume: 189 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1979 Mar |
Date Detail:
|
Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 290-3 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens* Cold Temperature Dimethyl Sulfoxide / pharmacology Freezing Glutaral / pharmacology Graft Rejection* Histocompatibility Humans Rats Rats, Inbred ACI Rats, Inbred Lew Skin / immunology Skin Transplantation Tissue Preservation / methods Transplantation, Homologous Veins / immunology, transplantation* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 111-30-8/Glutaral; 67-68-5/Dimethyl Sulfoxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: DL-ethionine treatment of adult pancreatic donors. Amelioration of diabetes in multiple recipients w...
Next Document: Liver failure with steatonecrosis after jejunoileal bypass: recovery with parenteral nutriton and re...