Document Detail

Antigenic variation of surface proteins of Borrelia species.
MedLine Citation:
PMID:  3055207     Owner:  NLM     Status:  MEDLINE    
During relapsing fever, the etiologic spirochetes employ antigenic variation to avoid early immune clearance. In Borrelia hermsii, an agent of tick-borne relapsing fever, a switch in serotype is associated with a change in the predominant protein on the surface of the cells. The variable major proteins differ from one another in primary structure along their lengths. Genes encoding the different variable major proteins can be found in both "silent" and "active" environments. At the active site the gene is expressed; at the silent site the gene appears to be in storage. In variant cells, which express the new serotype-specific surface protein in a population, a gene from a silent site has replaced the previously sitting gene at the active site through transposition.
A G Barbour
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  10 Suppl 2     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1988-12-12     Completed Date:  1988-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S399-402     Citation Subset:  IM    
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758.
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MeSH Terms
Antigenic Variation
Antigens, Bacterial / genetics,  immunology*
Antigens, Surface / genetics,  immunology
Borrelia / genetics,  immunology*
Grant Support
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, Surface

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