| Antigenic variation of surface proteins of Borrelia species. | |
| | |
MedLine Citation:
|
PMID: 3055207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During relapsing fever, the etiologic spirochetes employ antigenic variation to avoid early immune clearance. In Borrelia hermsii, an agent of tick-borne relapsing fever, a switch in serotype is associated with a change in the predominant protein on the surface of the cells. The variable major proteins differ from one another in primary structure along their lengths. Genes encoding the different variable major proteins can be found in both "silent" and "active" environments. At the active site the gene is expressed; at the silent site the gene appears to be in storage. In variant cells, which express the new serotype-specific surface protein in a population, a gene from a silent site has replaced the previously sitting gene at the active site through transposition. |
| | |
Authors:
|
A G Barbour |
Related Documents
:
|
21617847 - Leptin gene transfer regulates fibromuscular development and lipid deposition in muscle... 1651407 - Complex regulation of transcription from the hepatitis b virus major surface antigen pr... 15511667 - Regulating self-tolerance by deregulating gene expression. 22360857 - Relative susceptibility and transcriptional response of nitrogen cycling bacteria to qu... 10950117 - Differentially expressed genes in two lncap prostate cancer cell lines reflecting chang... 17471237 - Epigenetic regulation (dna methylation, histone modifications) of the 11p15 mucin genes... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Reviews of infectious diseases Volume: 10 Suppl 2 ISSN: 0162-0886 ISO Abbreviation: Rev. Infect. Dis. Publication Date: 1988 Jul-Aug |
Date Detail:
|
Created Date: 1988-12-12 Completed Date: 1988-12-12 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7905878 Medline TA: Rev Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: S399-402 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284-7758. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigenic Variation Antigens, Bacterial / genetics, immunology* Antigens, Surface / genetics, immunology Borrelia / genetics, immunology* Humans |
| Grant Support | |
ID/Acronym/Agency:
|
AI 24424/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Bacterial; 0/Antigens, Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein antigens of genital mycoplasmas.
Next Document: Identification, cloning, and purification of protein antigens of Treponema pallidum.