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Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia.
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MedLine Citation:
PMID:  327016     Owner:  NLM     Status:  MEDLINE    
Friend leukemia virus (FLV) erythroleukemic cells cultured in medium containing FLV-immune serum from dormant FLV-infected mice undergo modulation of FLV cell surface antigens. Modulation was determined by an increased resistance to FLV antibody-mediated complement-dependent lysis and was associated temporally with the capping of FLV-immune complexes at the cell surface. Modulated cells regained their susceptibility to FLV antibody-mediated complement-dependent lysis when transferred to medium containing normal mouse serum. After 48 h of culture in FLV-immune serum, 26% of the FLV erythroleukemic cells were devoid of FLV cell surface antigens as demonstrated by immunofluoresence. Antigenic modulation occurred to a greater extent in cells maintained in logarithmic growth than in cells in GO or resting phase. FLV-antigenic modulation is discussed as a possible mechanism by which antibody induces and maintains FLV-transformed cells in a dormant state.
E V Genovesi; P A Marx; E F Wheelock
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  146     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  520-34     Citation Subset:  AIM; IM    
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MeSH Terms
Antigen-Antibody Complex
Antigens, Viral* / analysis
Cell Line
Clone Cells
Cytotoxicity Tests, Immunologic
Fluorescent Antibody Technique
Friend murine leukemia virus / immunology*
Immune Sera / pharmacology*
Immunoglobulin G / analysis
Leukemia, Erythroblastic, Acute / immunology*
Mice, Inbred DBA / immunology
Tumor Virus Infections / immunology*
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Antigens, Viral; 0/Immune Sera; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 8 Year: 1977
Volume: 146 Issue: 2
First Page: 520 Last Page: 534
ID: 2180763
Publisher Id: 77208876
PubMed Id: 327016

Antigenic modulation of Friend virus erythroleukemic cells in vitro by serum from mice with dormant erythroleukemia

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