Document Detail


Antigenic diversity found in isolates of Plasmodium falciparum from Papua New Guinea by using monoclonal antibodies.
MedLine Citation:
PMID:  6201077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monoclonal antibodies were used to demonstrate antigenic diversity in over 100 primary isolates of Plasmodium falciparum collected from one area of Papua New Guinea. The frequencies of several parasite antigens in our sample is calculated. One particular antigen which had previously been shown to be absent in one-third of established isolates collected from several countries appeared ubiquitous in our sample from Papua New Guinea. A method is presented that can be used to test for associations between antigens; the analysis also reveals whether other variables affect these associations. Several associations between antigens were revealed. In one instance, the association between two particular parasite antigens was affected by the donor's age. The importance of characterizing the antigenic structure of P. falciparum populations, and its relevance to the introduction of an antimalarial vaccine are discussed.
Authors:
G Knowles; W L Davidson; J S McBride; D Jolley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  33     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-10     Completed Date:  1984-05-10     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Antibodies, Monoclonal / immunology*
Child
Epitopes / immunology*
Fluorescent Antibody Technique
Host-Parasite Interactions
Humans
Malaria / parasitology
Papua New Guinea
Plasmodium falciparum / growth & development,  immunology*,  isolation & purification
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Epitopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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