Document Detail


Antigen-specific therapeutic approaches in Type 1 diabetes.
MedLine Citation:
PMID:  22355799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of strategies capable of specifically curbing pathogenic autoimmune responses in a disease- and organ-specific manner without impairing foreign or tumor antigen-specific immune responses represents a long sought-after goal in autoimmune disease research. Unfortunately, our current understanding of the intricate details of the different autoimmune diseases that affect mankind, including type 1 diabetes, is rudimentary. As a result, progress in the development of the so-called "antigen-specific" therapies for autoimmunity has been slow and fraught with limitations that interfere with bench-to-bedside translation. Absent or incomplete understanding of mechanisms of action and lack of adequate immunological biomarkers, for example, preclude the rational design of effective drug development programs. Here, we provide an overview of antigen-specific approaches that have been tested in preclinical models of T1D and, in some cases, human subjects. The evidence suggests that effective translation of these approaches through clinical trials and into patients will continue to meet with failure unless detailed mechanisms of action at the level of the organism are defined.
Authors:
Xavier Clemente-Casares; Sue Tsai; Carol Huang; Pere Santamaria
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2013-06-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a007773     Citation Subset:  IM    
Affiliation:
Julia McFarlane Diabetes Research Centre, University of Calgary, NW Calgary, Alberta T2N 4N1, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens / therapeutic use*
Chaperonin 60 / therapeutic use
Clinical Trials as Topic
Dendritic Cells / immunology
Diabetes Mellitus, Type 1 / therapy*
Disease Models, Animal
Drug Evaluation
Enzyme Inhibitors / therapeutic use
Glutamate Decarboxylase / antagonists & inhibitors
Humans
Hypoglycemic Agents / therapeutic use
Immunotherapy / methods*
Insulin / therapeutic use
Vaccines, DNA / therapeutic use
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antigens; 0/Chaperonin 60; 0/Enzyme Inhibitors; 0/Hypoglycemic Agents; 0/Insulin; 0/Vaccines, DNA; EC 4.1.1.15/Glutamate Decarboxylase
Comments/Corrections

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