Document Detail

Antigen-specific peripheral immune responses are unaltered during normal pregnancy in sheep.
MedLine Citation:
PMID:  17826845     Owner:  NLM     Status:  MEDLINE    
A shift in the balance of T(Helper) (T(H))1/T(H)2 cytokine production by maternal peripheral blood leukocytes is regarded as a common important feature of successful mammalian pregnancy. Although the phenomenon has been studied extensively in animals with invasive hemochorial placentae, the paradigm has not been studied in detail in species with less-invasive placentae, such as sheep that have a synepitheliochorial placenta. Sixteen sheep were immunised with the nominal antigen chicken egg albumin (Ova) and antigen-specific humoral and cellular responses were established in all sheep. The 16 sheep were synchronised, 11 were mated and successfully conceived, the remaining 5 served as non-pregnant controls. Peripheral blood mononuclear cells (PBMC) were isolated approximately every 2 weeks and restimulated in vitro with either Ova or the T cell mitogen concanavalin A (ConA), and cell proliferation and cytokine production measured. There were no detectable differences in antigen-driven PBMC proliferation, interferon-gamma (IFN-gamma), interleukin (IL)-4 or IL-10 production between pregnant and non-pregnant sheep. Also, there were no appreciable differences in ConA-induced IFN-gamma, IL-4 or IL-10 between the groups. These data suggest that a shift in T(H)1/T(H)2 cytokine production does not occur in pregnant sheep and indicate that further comparative reproductive immunology studies on species with non-invasive placentation will be informative of materno-fetal interactions and immune regulation during pregnancy.
S Wattegedera; M Rocchi; J Sales; C J Howard; J C Hope; G Entrican
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-10
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  77     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  171-8     Citation Subset:  IM    
Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, UK.
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MeSH Terms
Cell Proliferation
Cytokines / immunology,  secretion
Immunity, Cellular / drug effects,  immunology*
Immunoglobulins / blood
Leukocytes, Mononuclear / immunology
Maternal-Fetal Exchange
Ovalbumin / administration & dosage
Pregnancy, Animal / blood,  immunology*
Th1 Cells / drug effects,  immunology*
Th2 Cells / drug effects,  immunology*
Grant Support
//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Cytokines; 0/Epitopes; 0/Immunoglobulins; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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