| Antigen-presenting cell function in the tolerogenic liver environment. | |
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MedLine Citation:
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PMID: 20972472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The demands that are imposed on the liver as a result of its function as a metabolic organ that extracts nutrients and clears gut-derived microbial products from the blood are met by a unique microanatomical and immunological environment. The inherent tolerogenicity of the liver and its role in the regulation of innate and adaptive immunity are mediated by parenchymal and non-parenchymal antigen-presenting cells (APCs), cell-autonomous molecular pathways and locally produced factors. Here, we review the central role of liver APCs in the regulation of hepatic immune function and also consider how recent insights may be applied in strategies to target liver tolerance for disease therapy. |
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Authors:
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Angus W Thomson; Percy A Knolle |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 10 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 753-66 Citation Subset: IM |
Affiliation:
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Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. thomsonaw@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / immunology* Humans Immune Tolerance / immunology* Immunotherapy Liver / cytology, immunology* Liver Diseases / immunology, therapy |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI81678/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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