Document Detail

Antigen-induced histamine-release from duodenal biopsy in gastrointestinal food allergy.
MedLine Citation:
PMID:  2470274     Owner:  NLM     Status:  MEDLINE    
Twenty-four patients allergic to food, which was demonstrated by oral provocation, were investigated. Six particles from duodenal mucosa were obtained during endoscopic examination and incubated with different foods. Specimens challenged by anti-human-IgE or without any stimulus served as control values. Also, skin tests and assays of specific IgE were performed. The spontaneous histamine release varied from 19% to 36%. Anti-IgE caused an increase up to 26% until 65%. Incubation with allergenic food induced a histamine release from 41% to 81%, demonstrating positive results in 27 out of 30 separate experiments. Antigen-induced histamine release from biopsy specimens turned out superior to skin tests and specific IgE. It is the most reliable tool for diagnosis of gastrointestinal food allergy besides oral provocation.
H W Baenkler; G Lux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy     Volume:  62     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
Department of Medicine, University Hospital, Erlangen, Germany.
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MeSH Terms
Antigens / pharmacology*
Duodenum / pathology*
Food Hypersensitivity / diagnosis*,  metabolism
Histamine Release*
Immunoglobulin E / analysis
Middle Aged
Skin Tests
Reg. No./Substance:
0/Antigens; 37341-29-0/Immunoglobulin E

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