| Antigen-dependent selection of T cells that are able to efficiently regulate free cytoplasmic Ca2+ levels. | |
| | |
MedLine Citation:
|
PMID: 8027538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In T helper cells, the process of memory acquisition is reflected in the expression of phenotypic markers. However, little is known regarding the functional changes that occurred in T helper cells selected after a primary Ag-specific response. We now present data that indicate that such T helper cells acquire the ability to down-regulate high concentrations of free cytoplasmic Ca2+. This property renders them resistant to intense inductive stimuli, such as high concentrations of ionomycin. The accumulation of cells that display this ability parallels the progressive proliferative enrichment of Ag-specific T cells and correlates with the surface expression of the CD45RB(low) isoform. As previously shown, persistent high levels of cytoplasmic Ca2+ are responsible for death via apoptosis in virgin T cells. In contrast, the ability to regulate cytosolic Ca2+ allows survival and clonal expansion. We suggest that memory T cells behave differently from virgin T cells when interacting with Ag-presenting B cells (as reported by others) because they have acquired this new physiologic property. Ag-presenting B cells deliver an intense stimulatory signal to T cells because of a high multiplicity of cognate interactions. Thus, Ag-driven T cell proliferation results in the selection of "resistant" T helper cells that can be successfully stimulated by memory B cells. In contrast, naive T cells, which cannot modulate high levels of cytosolic Ca2+, are deleted as a consequence of Ag presentation by B cells. |
| | |
Authors:
|
R Rajasekar; A Augustin |
Related Documents
:
|
20380478 - Micro-raman detection of nuclear membrane lipid fluctuations in senescent epithelial br... 19695678 - Polycomb group protein bmi1 is overexpressed and essential in anchorage-independent col... 20352028 - Cellular senescence is a common characteristic shared by preneoplasic and osteo-arthrit... 20043098 - Fibroblasts from werner syndrome patients: cancer cells derived by experimental introdu... 6771298 - Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pit... 15032398 - Induction of inflammatory cell accumulation using human mast cell tryptases. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 153 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1994-08-09 Completed Date: 1994-08-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1037-45 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens / immunology Calcium / metabolism* Cytosol / metabolism Immunologic Memory* Ionomycin / pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Ovalbumin / immunology Receptors, Nicotinic / immunology T-Lymphocytes / metabolism* T-Lymphocytes, Helper-Inducer / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Receptors, Nicotinic; 56092-81-0/Ionomycin; 7440-70-2/Calcium; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunohistochemical detection of the androgen receptor with monoclonal antibody F39.4 in routinely p...
Next Document: Glycosyl phosphatidylinositol membrane anchor is not required for T cell activation through CD73.