| Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes. | |
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MedLine Citation:
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PMID: 20147961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Keratinocytes expressing tumor or viral antigens can be eliminated by antigen-primed CD8 cytotoxic T cells. CD4 T-helper cells help induction of CD8 cytotoxic T cells from naive precursors and generation of CD8 T-cell memory. In this study, we show, unexpectedly, that CD4 cells are also required to assist primed CD8 effector T cells in rejection of skin expressing human growth hormone, a neo-self-antigen, in keratinocytes. The requirement for CD4 cells can be substituted by CD40 costimulation. Rejection of skin expressing ovalbumin (OVA), a non-self-antigen, by primed CD8 cytotoxic T cells can in contrast occur without help from antigen-specific CD4 T cells. However, rejection of OVA expressing keratinocytes is helped by antigen-specific CD4 T cells if only low numbers of primed or naive OVA-specific CD8 T cells are available. Effective immunotherapy directed at antigens expressed in squamous cancer may therefore be facilitated by induction of tumor antigen-specific CD4 helper T cells, as well as cytotoxic CD8 T cells. |
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Authors:
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Jennifer K Broom; Andrew M Lew; Hiroaki Azukizawa; Tony J Kenna; Graham R Leggatt; Ian H Frazer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-11 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 130 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1581-9 Citation Subset: IM |
Affiliation:
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Immunology and Metabolic Medicine, The University of Queensland Diamantina Institute for Cancer, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens / immunology* Antigens, CD40 / pharmacology Disease Models, Animal Graft Rejection / immunology, pathology, physiopathology Human Growth Hormone / immunology, metabolism Keratinocytes / drug effects, metabolism, pathology* Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Ovalbumin / immunology, metabolism Skin Transplantation / immunology, pathology*, physiology T-Lymphocytes, Cytotoxic / drug effects, immunology*, physiology T-Lymphocytes, Helper-Inducer / drug effects, immunology*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, CD40; 12629-01-5/Human Growth Hormone; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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