| Antigen Presentation Capacity of Dendritic Cells is Impaired in Ongoing Enterovirus-Myocarditis. | |
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MedLine Citation:
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PMID: 21630249 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Coxsackievirus B3 (CVB3)-infection is a frequent cause of acute myocarditis, which may result in chronic myocarditis and virus persistence. Investigation of initial immune responses may shed light on the mechanisms that contribute to ongoing disease. Dendritic cells (DCs) as key professional antigen-presentating cells were investigated in two MHC-matched hosts: while C57BL/6 mice are resistant to chronic disease, the A.BY/SnJ mouse strain exhibits susceptibility to chronic CVB3-myocarditis. DC maturation and activation were critically impaired in A.BY/SnJ mice, which were reflected by the failure to induce co-stimulatory molecules and cytokine/chemokine responses. Also, MHC class I-restricted antigen presentation via the cross-presentation pathway was affected in DCs from A.BY/SnJ mice. The accumulation of dendritic cell aggresome-like induced structures (DALISs), a process in DC maturation involving the transient storage of poly-ubiquitinylated DRIPs, was found to be of permanent nature in DCs from A.BY/SnJ mice: detection of trapped poly-ubiquitinylated CVB3 proteins in these DALISs suggested a limitation in the MHC class I antigenic peptide supply in this host. In conclusion, ongoing chronic disease in A.BY/SnJ mice due to a failure to clear the virus may be attributed to defects in DC maturation/activation and DC MHC class I antigen processing. |
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Authors:
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Anna Rahnefeld; Frédéric Ebstein; Nadine Albrecht; Elisa Opitz; Ulrike Kuckelkorn; Karl Stangl; Armin Rehm; Peter M Kloetzel; Antje Voigt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
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Title: European journal of immunology Volume: - ISSN: 1521-4141 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Clinic for Cardiology and Angiology, Campus Mitte, Charité-Universitätsmedizin Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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