Document Detail

Antifungal treatment in sarcoidosis--a pilot intervention trial.
MedLine Citation:
PMID:  16982183     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sarcoidosis is generally treated with corticosteroids that are not always an effective therapy. OBJECTIVES: To assess if treatment with antifungal drugs would improve the clinical status of patients with sarcoidosis. METHODS: Patients (n=18) with sarcoidosis grades II and III according to established criteria and without clinical and immunological signs of fungal infection, were treated with antifungal medication together with corticosteroids for 3-6 months. Pulmonary X-ray infiltration, lung function, and severity of symptoms were registered before and after the treatment and at follow up 9-58 months later. RESULTS: The treatment resulted in statistically significant decreases in the degree of pulmonary infiltration with an average decrease in the group from 2.0 to 1.0. There were also significant increases in diffusion capacity and decreases in the severity of symptoms. CONCLUSION: It is suggested that treatment with antifungal drugs may be useful, at least in certain cases of sarcoidosis.
Marjeta Tercelj; Tomaz Rott; Ragnar Rylander
Related Documents :
17664713 - Long-term safety and toxicity of azathioprine in patients with air-borne contact dermat...
20493183 - Biomarkers of oxidation, inflammation and cartilage degradation in osteoarthritis patie...
21050233 - A new composite model including metabolic syndrome, alanine aminotransferase and cytoke...
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-09-18
Journal Detail:
Title:  Respiratory medicine     Volume:  101     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  IM    
Unit of Respiratory Diseases and Allergy, University Medical Center, Clinical Center, Zaloska 7, 1525 Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Antifungal Agents / therapeutic use*
Drug Therapy, Combination
Fluconazole / therapeutic use
Itraconazole / therapeutic use
Ketoconazole / therapeutic use
Middle Aged
Pilot Projects
Sarcoidosis / drug therapy*,  physiopathology
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury...
Next Document:  Nanocrystalline silicon-based oligonucleotide chips.