| Antifungal treatment in sarcoidosis--a pilot intervention trial. | |
| | |
MedLine Citation:
|
PMID: 16982183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Sarcoidosis is generally treated with corticosteroids that are not always an effective therapy. OBJECTIVES: To assess if treatment with antifungal drugs would improve the clinical status of patients with sarcoidosis. METHODS: Patients (n=18) with sarcoidosis grades II and III according to established criteria and without clinical and immunological signs of fungal infection, were treated with antifungal medication together with corticosteroids for 3-6 months. Pulmonary X-ray infiltration, lung function, and severity of symptoms were registered before and after the treatment and at follow up 9-58 months later. RESULTS: The treatment resulted in statistically significant decreases in the degree of pulmonary infiltration with an average decrease in the group from 2.0 to 1.0. There were also significant increases in diffusion capacity and decreases in the severity of symptoms. CONCLUSION: It is suggested that treatment with antifungal drugs may be useful, at least in certain cases of sarcoidosis. |
| | |
Authors:
|
Marjeta Tercelj; Tomaz Rott; Ragnar Rylander |
Related Documents
:
|
20937573 - Intra-lesional steriod for the management of symptomatic infantile digital fibromatosis. 16595563 - Presenting characteristics as predictors of duration of treatment in sarcoidosis. 22773233 - Randomized clinical trial of laparoscopic hernia repair comparing titanium-coated light... |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2006-09-18 |
Journal Detail:
|
Title: Respiratory medicine Volume: 101 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-05 Completed Date: 2007-06-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
|
Languages: eng Pagination: 774-8 Citation Subset: IM |
Affiliation:
|
Unit of Respiratory Diseases and Allergy, University Medical Center, Clinical Center, Zaloska 7, 1525 Ljubljana, Slovenia. marjeta.tercelj@kclj.si |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Adult Aged Antifungal Agents / therapeutic use* Drug Therapy, Combination Female Fluconazole / therapeutic use Humans Itraconazole / therapeutic use Ketoconazole / therapeutic use Male Middle Aged Pilot Projects Sarcoidosis / drug therapy*, physiopathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury...
Next Document: Nanocrystalline silicon-based oligonucleotide chips.