Document Detail


Antifungal treatment in sarcoidosis--a pilot intervention trial.
MedLine Citation:
PMID:  16982183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sarcoidosis is generally treated with corticosteroids that are not always an effective therapy. OBJECTIVES: To assess if treatment with antifungal drugs would improve the clinical status of patients with sarcoidosis. METHODS: Patients (n=18) with sarcoidosis grades II and III according to established criteria and without clinical and immunological signs of fungal infection, were treated with antifungal medication together with corticosteroids for 3-6 months. Pulmonary X-ray infiltration, lung function, and severity of symptoms were registered before and after the treatment and at follow up 9-58 months later. RESULTS: The treatment resulted in statistically significant decreases in the degree of pulmonary infiltration with an average decrease in the group from 2.0 to 1.0. There were also significant increases in diffusion capacity and decreases in the severity of symptoms. CONCLUSION: It is suggested that treatment with antifungal drugs may be useful, at least in certain cases of sarcoidosis.
Authors:
Marjeta Tercelj; Tomaz Rott; Ragnar Rylander
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-09-18
Journal Detail:
Title:  Respiratory medicine     Volume:  101     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  IM    
Affiliation:
Unit of Respiratory Diseases and Allergy, University Medical Center, Clinical Center, Zaloska 7, 1525 Ljubljana, Slovenia. marjeta.tercelj@kclj.si
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Aged
Antifungal Agents / therapeutic use*
Drug Therapy, Combination
Female
Fluconazole / therapeutic use
Humans
Itraconazole / therapeutic use
Ketoconazole / therapeutic use
Male
Middle Aged
Pilot Projects
Sarcoidosis / drug therapy*,  physiopathology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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