Document Detail


Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.
MedLine Citation:
PMID:  22024829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ≥2 μg/ml and micafungin minimum effective concentrations (MECs) of ≥16 μg/ml were recorded for two and one isolates, respectively.
Authors:
Masato Tashiro; Koichi Izumikawa; Asuka Minematsu; Katsuji Hirano; Naoki Iwanaga; Shotaro Ide; Tomo Mihara; Naoki Hosogaya; Takahiro Takazono; Yoshitomo Morinaga; Shigeki Nakamura; Shintaro Kurihara; Yoshifumi Imamura; Taiga Miyazaki; Tomoya Nishino; Misuzu Tsukamoto; Hiroshi Kakeya; Yoshihiro Yamamoto; Katsunori Yanagihara; Akira Yasuoka; Takayoshi Tashiro; Shigeru Kohno
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Publication Detail:
Type:  Journal Article     Date:  2011-10-24
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-27     Completed Date:  2012-08-02     Revised Date:  2013-12-10    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  584-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution
Amphotericin B / administration & dosage
Antifungal Agents / administration & dosage*
Aspergillosis / drug therapy*,  microbiology
Aspergillus fumigatus / drug effects*,  genetics,  isolation & purification
Cytochrome P-450 Enzyme System / genetics*
Drug Resistance, Fungal / drug effects
Echinocandins / administration & dosage
Female
Fungal Proteins / genetics*
Humans
Itraconazole / administration & dosage
Japan
Lipopeptides / administration & dosage
Male
Microbial Sensitivity Tests
Mutation
Pyrimidines / administration & dosage
Sequence Analysis, DNA
Triazoles / administration & dosage
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/Fungal Proteins; 0/Lipopeptides; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 304NUG5GF4/Itraconazole; 6TK1G07BHZ/posaconazole; 7XU7A7DROE/Amphotericin B; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.-/cytochrome P-450 CYP51A, Aspergillus; R10H71BSWG/micafungin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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