Document Detail


Antifungal sordarins. part 3: synthesis and structure-activity relationships of 2',3'-fused oxirane derivatives.
MedLine Citation:
PMID:  11992779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A number of new 2',3'-fused oxirane derivatives were synthesized for structure-activity relationship study. Many of these derivatives exhibit high potency against Candida spp. In addition, sordarin manno epoxide derivative 6 presents in vivo therapeutic effect in mice and is considered a promising antifungal lead within this series.
Authors:
Julia Castro; Juan C Cuevas; José M Fiandor; Ma Teresa Fraile; Federico Gómez de las Heras; José R Ruiz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  12     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-09-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  1371-4     Citation Subset:  IM    
Affiliation:
GlaxoSmithKline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemical synthesis*,  chemistry*,  pharmacology
Candida / drug effects*
Drug Design
Epoxy Compounds / chemical synthesis,  chemistry,  pharmacology
Ethylene Oxide / analogs & derivatives*,  chemical synthesis*,  chemistry,  pharmacology
Indenes
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Epoxy Compounds; 0/Indenes; 11076-17-8/sordarin; 75-21-8/Ethylene Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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