| Antifungal prophylaxis in pediatric hematology/oncology: new choices & new data. | |
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MedLine Citation:
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PMID: 22102607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A severe complication of the treatment of pediatric cancers is the development of an invasive fungal infection (IFI). The data to support antifungal prophylaxis in pediatric oncology patients derive primarily from adult patients, and thus the optimal agent to utilize is not clear. Fluconazole has been a standard option, but agents with antimold activity are now available, each with limitations. Pediatric dosing for voriconazole and posaconazole is uncertain and multiple drug interactions exist. The echinocandins are well-tolerated, but only available in intravenous form. Ultimately, studies demonstrating biologic risk factors for the development of IFI may lead to personalized prophylactic strategies. |
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Authors:
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Christopher C Dvorak; Brian T Fisher; Lillian Sung; William J Steinbach; Michael Nieder; Sarah Alexander; Theoklis E Zaoutis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-11-18 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 59 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-05-18 Completed Date: 2012-07-16 Revised Date: 2012-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Division of Pediatric Blood & Marrow Transplant, Department of Pediatrics, University of California San Francisco, San Francisco, California 94143-1278, USA. dvorakc@peds.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antifungal Agents / adverse effects, therapeutic use* Child Child, Preschool Female Hematologic Neoplasms / therapy* Humans Infant Male Mycoses / mortality, prevention & control* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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U10 CA098543/CA/NCI NIH HHS; U10 CA98543-08/CA/NCI NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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