Document Detail


Antifungal properties of n-alkanols, alpha, omega-n-alkanediols, and omega-chloro-alpha-alkanols.
MedLine Citation:
PMID:  7373528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fourteen n-alkanols (C1-C12, C14, and C16), 13 alpha,omega-n-alkanediols (C2-C12, C14, and C16), and 13 omega-chloro-alpha-alkanols (C2-C12, C14, and C16) were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verucaria in Sabouraud dextrose agar at pH 4.0 and 5.6. Toxicity to Candida blbicans, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. The fungitoxicity of these alcohols was influenced by chain length and insignificantly by the pH of the medium and the presence of beef serum. The C10-member of each series was most active; the order of activity of the three groups was chloroalkanols greater than alkanols greater than alkanediols. Compared to the fatty acids, the order of fungitoxicity on a weight basis was 2-alkynoic acids greater than 2-alkenoic acids greater than omega-chloralkanols greater than alkanoic acids greater than 2-bromoalkanoic acids greater than 2-fluoroalkanoic acids greater than n-alkoxyacetic acids greater than n-alkanols greater than alpha,omega-n-alkanediols.
Authors:
H Gershon; L Shanks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  69     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohols / pharmacology*
Antifungal Agents*
Chlorohydrins / pharmacology*
Fungi / drug effects
Glycols / pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Alcohols; 0/Antifungal Agents; 0/Chlorohydrins; 0/Glycols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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