Document Detail


Antifungal properties of 2-alkenoic acids and 2-bromo alkanoic acids.
MedLine Citation:
PMID:  4791305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antifungal activity of homologous series of 2-alkenoic and 2-bromo alkanoic acids was determined against Aspergillus niger, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes and compared with data on analogous alkanoic and 2-fluoro alkanoic acids. The fungitoxicity of all of the series of compounds was determined by chain length, pH of the medium, and presence or absence of adsorbents such as serum albumin. The order of toxicity on a molecular basis, by using a scale where the most active series is 1.0, is 2-bromo alkanoic acids (1.0) > 2-fluoro alkanoic acids (1.2) > alkanoic acids (1.4) > 2-alkenoic acids (2.5).
Authors:
H Gershon; M W McNeil; R Parmegiani; P K Godfrey; J M Baricko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  4     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1973 Oct 
Date Detail:
Created Date:  1974-07-26     Completed Date:  1974-07-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents*
Aspergillus / drug effects
Bromine / pharmacology
Fatty Acids, Unsaturated / pharmacology*
Fatty Acids, Volatile / pharmacology
Fungi / drug effects
Hydrocarbons, Brominated / pharmacology*
Microbial Sensitivity Tests
Trichophyton / drug effects
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Fatty Acids, Unsaturated; 0/Fatty Acids, Volatile; 0/Hydrocarbons, Brominated; 7726-95-6/Bromine
Comments/Corrections

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