Document Detail

Antifungal efficacy of voriconazole, itraconazole and amphotericin b in experimental fusarium solani keratitis.
MedLine Citation:
PMID:  17912543     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy of topical voriconazole in an experimental rabbit model of Fusarium keratitis. METHODS: Fungal keratitis was induced in the right eyes of 24 New Zealand rabbits. 8.6 x 10(3) CFU/0.1 ml F.solani spore suspension was injected midstromally into the central cornea. Group 1 received topical amphotericin B 0.15%, group 2 received topical itraconazole 1% and group 3 received topical voriconazole 1% hourly between 08:00 to 22:00 on days 1 and 2; 4 times daily on days 3-5. Control group received topical balanced salt solution at identical intervals. The eyes were examined clinically with a scoring system before treatment (day 0), on day 3 and on day 5. Cultures were taken from the lesion by scraping at the end of the treatment. Clinical scores and microbiologic results were analyzed statistically. RESULTS: In the control group, keratitis progressed clinically and colony level was 2 x 10(3) CFU at day 5. In all treatment groups, progression of keratitis was inhibited clinically. Culture was sterile in the group receiving amphotericin B. Colony level was 0.3 x 10(2) CFU in the itraconazole group and 2 x 10(2) CFU in the voriconazole group at day 5. CONCLUSION: Progression of keratitis was inhibited clinically in all treatment groups. Colony level decreased significantly in all treatment groups. As a result, itraconazole 1% and voriconazole 1% were found to be effective in Fusarium keratitis clinically and microbiologically, although their activity was not as effective as amphotericin B 0.15%.
Güliz Fatma Yavas; Faruk Oztürk; Tuncay Küsbeci; Zafer Cetinkaya; Sitki Samet Ermis; Nuri Kiraz; Umit Ubeyt Inan
Related Documents :
2275233 - Drugs for treatment of vulvovaginal candidiasis: comparative efficacy of agents and reg...
1636873 - The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers.
11222893 - Unicompartmental knee arthroplasty for lateral gonarthrosis: midterm results.
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-10-02
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  246     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  IM    
Department of Ophthalmology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Topical
Amphotericin B / administration & dosage
Antifungal Agents / administration & dosage*
Colony Count, Microbial
Corneal Ulcer / drug therapy*,  microbiology
Disease Models, Animal*
Eye Infections, Fungal / drug therapy*,  microbiology
Fusarium / isolation & purification*
Itraconazole / administration & dosage
Mycoses / drug therapy*,  microbiology
Pyrimidines / administration & dosage
Treatment Outcome
Triazoles / administration & dosage
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 1397-89-3/Amphotericin B; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Massive ovarian edema in pregnancy after ovulation induction using clomiphene citrate.
Next Document:  Chained learning architectures in a simple closed-loop behavioural context.