| Antifungal efficacy of voriconazole, itraconazole and amphotericin b in experimental fusarium solani keratitis. | |
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MedLine Citation:
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PMID: 17912543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of topical voriconazole in an experimental rabbit model of Fusarium keratitis. METHODS: Fungal keratitis was induced in the right eyes of 24 New Zealand rabbits. 8.6 x 10(3) CFU/0.1 ml F.solani spore suspension was injected midstromally into the central cornea. Group 1 received topical amphotericin B 0.15%, group 2 received topical itraconazole 1% and group 3 received topical voriconazole 1% hourly between 08:00 to 22:00 on days 1 and 2; 4 times daily on days 3-5. Control group received topical balanced salt solution at identical intervals. The eyes were examined clinically with a scoring system before treatment (day 0), on day 3 and on day 5. Cultures were taken from the lesion by scraping at the end of the treatment. Clinical scores and microbiologic results were analyzed statistically. RESULTS: In the control group, keratitis progressed clinically and colony level was 2 x 10(3) CFU at day 5. In all treatment groups, progression of keratitis was inhibited clinically. Culture was sterile in the group receiving amphotericin B. Colony level was 0.3 x 10(2) CFU in the itraconazole group and 2 x 10(2) CFU in the voriconazole group at day 5. CONCLUSION: Progression of keratitis was inhibited clinically in all treatment groups. Colony level decreased significantly in all treatment groups. As a result, itraconazole 1% and voriconazole 1% were found to be effective in Fusarium keratitis clinically and microbiologically, although their activity was not as effective as amphotericin B 0.15%. |
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Authors:
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Güliz Fatma Yavas; Faruk Oztürk; Tuncay Küsbeci; Zafer Cetinkaya; Sitki Samet Ermis; Nuri Kiraz; Umit Ubeyt Inan |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-10-02 |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 246 ISSN: 0721-832X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey. gkumbar@ttnet.net.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Amphotericin B / administration & dosage Animals Antifungal Agents / administration & dosage* Colony Count, Microbial Corneal Ulcer / drug therapy*, microbiology Disease Models, Animal* Eye Infections, Fungal / drug therapy*, microbiology Fusarium / isolation & purification* Itraconazole / administration & dosage Mycoses / drug therapy*, microbiology Pyrimidines / administration & dosage Rabbits Treatment Outcome Triazoles / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole; 1397-89-3/Amphotericin B; 84625-61-6/Itraconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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