Document Detail


Antifungal canthin-6-one series accumulate in lipid droplets and affect fatty acid metabolism in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  17888617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of action of antifungal canthin-6-one series was investigated in Saccharomyces cerevisiae. After a rapid uptake, a preferential accumulation of the drug within lipid droplets was observed. The antifungal action of canthin-6-one was found as reversible. Canthin-6-one did not exhibit affinity for sterols, and membrane ergosterol was not necessary for the antifungal activity since the MICs were similar on an ergosterol-deleted and the wild-type S. cerevisiae clones. Relative amount of unsaturated alkyl chain fatty acids was significantly enhanced suggesting a stimulation of desaturase enzyme systems. No synergistic effect was observed between canthin-6-one and amphotericin B, ketoconazole and caspofungine. Canthin-6-one should now be evaluated in vivo against fungal pathogens.
Authors:
D Lagoutte; V Nicolas; E Poupon; A Fournet; R Hocquemiller; D Libong; P Chaminade; P M Loiseau
Related Documents :
19515007 - In vitrouptake and antimycobacterial activity of liposomal usnic acid formulation.
12223747 - Evidence that a malate/inorganic phosphate exchange translocator imports carbon across ...
7782717 - Hindleg muscle energy and substrate balances in cold-exposed rats.
3811987 - Uptake of dehydroascorbic acid and ascorbic acid to isolated nerve terminals and secret...
8818817 - Propionate modulation of ruminal ketogenesis.
8581467 - Activation of phosphatidylinositol bisphosphate signal transduction pathway after exper...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-08-23
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  62     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-06-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacognosie et Chimiothérapie Antiparasitaire, UMR 8076 CNRS, Faculté de Pharmacie, Univ Paris-Sud, 92290 Châtenay-Malabry, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amphotericin B / pharmacology
Antifungal Agents / isolation & purification,  pharmacokinetics,  pharmacology*
Drug Synergism
Fatty Acid Desaturases / drug effects,  metabolism
Fatty Acids / metabolism
Indoles / isolation & purification,  pharmacology*
Ketoconazole / pharmacology
Microbial Sensitivity Tests
Naphthyridines / isolation & purification,  pharmacology*
Saccharomyces cerevisiae
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Fatty Acids; 0/Indoles; 0/Naphthyridines; 0/canthin-6-one; 1397-89-3/Amphotericin B; 65277-42-1/Ketoconazole; EC 1.14.19.-/Fatty Acid Desaturases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Preferences of patients receiving bisphosphonates--how to influence the therapeutic adherence.
Next Document:  In vitro models of acute and long-term continuous infection of human respiratory epithelial cells wi...