Document Detail


Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
MedLine Citation:
PMID:  12932139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bioassay-guided fractionation resulted in the isolation of four antifungal agents from the roots of Cudrania cochinchinensis. Two of these were new compounds, cudraxanthone S [1, 1,3,5,6-tetrahydroxy-2-(1,1-dimethyl-2-propenyl)xanthone] and cudraflavanone B (2, 2',4',5,7-tetrahydroxy-6-prenylflavanone). The remaining two compounds were known compounds, toxyloxanthone C (3) and wighteone (4). Among these compounds, 1, 3, and 4 exhibited antifungal activities against Cryptococcus neoformans, Aspergillusfumigatus, and A. nidulans (MICs = 2-8 microg/mL). Compounds 1 and 3 also showed antifungal activity against Candida glabrata (MICs = 4-8 microg/mL).
Authors:
Toshio Fukai; Makiko Yonekawa; Ai-Jun Hou; Taro Nomura; Han-Dong Sun; Jun Uno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  66     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-22     Completed Date:  2003-12-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1118-20     Citation Subset:  IM    
Affiliation:
School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.tohu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Aspergillus / drug effects*
Candida / drug effects*
Cryptococcus / drug effects*
Drugs, Chinese Herbal / chemistry,  isolation & purification*,  pharmacology
Molecular Structure
Moraceae / chemistry*
Plant Roots / chemistry
Xanthones / chemistry,  isolation & purification*,  pharmacology
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Drugs, Chinese Herbal; 0/Xanthones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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