Document Detail


Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
MedLine Citation:
PMID:  21067926     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In order to discover more promising antifungal agents, a series of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles (5a-r) were prepared and evaluated in vitro for their antifungal activities against seven phytopathogenic fungi. Especially compounds 5n and 5o exhibited more potent antifungal activities than or comparable to hymexazol, a commercially available agricultural fungicide at the concentration of 100 μg/mL. Preliminary structure-activity relationships study demonstrated that introduction of electron-donating substituents R(1) and R(2), and the proper length of substituent R(3) were usually very important for their antifungal activities.
Authors:
Hui Xu; Yang-Yang Wang
Related Documents :
7774026 - Optically active antifungal azoles. iv. synthesis and antifungal activity of (2r,3r)-3-...
19705386 - Design and synthesis of a series of piperazine-1-carboxamidine derivatives with antifun...
19589626 - Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazol...
15558956 - Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity.
25030296 - Interaction of tryptophan and related compounds with oxygen- and carbon-centered radicals.
20970146 - Highly efficient olefin oxidation catalysts based on regular nano-particles of titanium...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-25
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  7274-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A&F University, Yangling, China. orgxuhui@nwsuaf.edu.cn
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Selective elution of target protein from affinity resins by a simple reductant with a thiol group.
Next Document:  Biaryl modification of the 5'-terminus of one strand of a microRNA duplex induces strand specificity...