| Antifungal agents. 10. Synthesis and antifungal activities of aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl) methane derivatives. | |
| | |
MedLine Citation:
|
PMID: 7669167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Various aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl)methane derivatives have been synthesized and tested as antifungal agents. The new imidazoles have been obtained by the action of 1,1'-sulfinyldiimidazole on aryl-(isoquinolin-1-yl)carbinols, which have been prepared by standard procedures starting from isoquinoline. Among 44 test derivatives only a few have exhibited some antifungal activity, the most active compound (4e) being twofold less potent than miconazole, ketoconazole and bifonazole, used as standard drugs. |
| | |
Authors:
|
R Silvestri; E Pagnozzi; F Troccoli; G Stefancich; S Massa; G Apuzzo; M E Perazzi; M Artico; G Simonetti |
Related Documents
:
|
17979247 - Minor sesquiterpene lactones from centaurea pullata and their antimicrobial activity. 21376357 - Assessment of routine malaria diagnosis in the venezuelan amazon. 22138617 - Ecvam prevalidation study on in vitro cell transformation assays: general outline and c... 19923777 - Microcalorimetric and manometric tests to assess anammox activity. 22354607 - Survey of audiological immittance practices. 4604087 - An experimental assessment of different anaerobic blood culture methods. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Farmaco (Società chimica italiana : 1989) Volume: 50 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-10-18 Completed Date: 1995-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8912641 Medline TA: Farmaco Country: ITALY |
Other Details:
|
Languages: eng Pagination: 227-38 Citation Subset: IM |
Affiliation:
|
Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Roma, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antifungal Agents
/
chemical synthesis,
pharmacology* Candida / drug effects Candida albicans / drug effects Imidazoles / chemical synthesis, pharmacology* Isoquinolines / chemical synthesis, pharmacology* Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Imidazoles; 0/Isoquinolines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The research career interests of graduating medical students.
Next Document: Synthesis and adrenergic beta-blocking activity of ortho-, meta- and para-oxypropanolamino-substitut...