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Antifungal activity of bis-azasqualenes, inhibitors of oxidosqualene cyclase.
MedLine Citation:
PMID:  19549106     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The antifungal activity and in vitro toxicity toward animal cells of two inhibitors of oxidosqualene cyclase, squalene bis-diethylamine (SBD) and squalene bis-diethylmethylammonium iodide (SBDI) were studied. Minimum inhibitory concentration (MIC) against dermatophytes and other fungi involved in cutaneous and systemic infections (12 isolates from seven species) were determined by the broth microdilution method based on the reference documents M38-A and M27-A2 of Clinical and Laboratory Standards Institute (CLSI). Both compounds exerted fungistatic activities, although with different action. SBDI was the more active compound and displayed low MIC values (in the 3.12-12.5 μg ml(-1) range) against Microsporum canis, Trichophyton mentagrophytes and one isolate of Scopulariopsis brevicaulis, while SBD showed MIC values against these species in the 3.12-25 μg ml(-1) range. Toxicity was tested on Madin-Darby canine kidney (MDCK) epithelial cells and human microvascular endothelial cells (HMEC). SBDI proved the less toxic compound: it inhibited M. canis, T. mentagrophytes and S. brevicaulis at concentrations below those found toxic for MDCK cells. HMEC were the more sensitive cells.
Authors:
Samuele Voyron; Flavio Rocco; Maurizio Ceruti; Paolo Forni; Alessandra Fiorio Pla; Maria Grazia Sarpietro; Giovanna Cristina Varese; Valeria Filipello Marchisio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mycoses     Volume:  53     ISSN:  1439-0507     ISO Abbreviation:  Mycoses     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  481-7     Citation Subset:  IM    
Copyright Information:
© 2009 Blackwell Verlag GmbH.
Affiliation:
Dipartimento di Biologia Vegetale, Università degli Studi di Torino, Torino, Italy.
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