Document Detail

Antifungal efficacy of 5.25% sodium hypochlorite, 2% chlorhexidine gluconate, and 17% EDTA with and without an antifungal agent.
MedLine Citation:
PMID:  20307743     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of this in vitro study was to evaluate the efficacy of 5.25% sodium hypochlorite (NaOCl), 2% chlorhexidine gluconate (CHX), and 17% EDTA as a final irrigant with and without the inclusion of an antifungal agent (1% clotrimazole) on Candida albicans.
METHODS: Sixty-five single-rooted instrumented and inoculated with a suspension of C. albicans. The experimental specimens were divided into two groups. The irrigant group was divided into three subgroups and irrigated with 5.25% NaOCl, 2% CHX, and 17% EDTA, respectively. The irrigant with antifungal group was divided into three subgroups and irrigated with 5.25% NaOCl, 2% CHX, and 17% EDTA respectively followed by 1% clotrimazole. Aliquots from the experimental teeth were plated on 4% Sabouraud agar (Tital Biotech, Delhi, India), and the colony-forming units (CFUs) were evaluated under light microscopy (400x).
RESULTS: NaOCl, 5.25%, exhibited superior antifungal efficacy compared with 2% CHX and 17% EDTA (p < 0.001). On inclusion of 1% clotrimazole, there was a significant decrease in the CFU (p < 0.001); 5.25% NaOCl and 2% CHX with clotrimazole showed significantly greater antifungal properties than 17% EDTA with clotrimazole (p < 0.001).
CONCLUSION: One percent of clotrimazole proved to be effective against C. albicans when used along with root canal irrigants as a final rinse.
Saurabh S Chandra; Revathi Miglani; M R Srinivasan; Rajamani Indira
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of endodontics     Volume:  36     ISSN:  1878-3554     ISO Abbreviation:  J Endod     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-18     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  675-8     Citation Subset:  D    
Copyright Information:
Copyright (c) 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Department of Conservative Dentistry and Endodontics, Ragas Dental College and Hospital, Chennai, India.
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MeSH Terms
Analysis of Variance
Antifungal Agents / pharmacology*
Candida albicans / drug effects*
Chlorhexidine / analogs & derivatives*,  pharmacology
Clotrimazole / pharmacology*
Colony Count, Microbial
Drug Combinations
Edetic Acid / pharmacology*
Root Canal Irrigants / pharmacology*
Sodium Hypochlorite / pharmacology*
Statistics, Nonparametric
Reg. No./Substance:
0/Antifungal Agents; 0/Drug Combinations; 0/Root Canal Irrigants; 23593-75-1/Clotrimazole; 55-56-1/Chlorhexidine; 60-00-4/Edetic Acid; 7681-52-9/Sodium Hypochlorite; MOR84MUD8E/chlorhexidine gluconate

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