Document Detail


Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii.
MedLine Citation:
PMID:  20657496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.
Authors:
Bomi Hwang; Juneyoung Lee; Qing-He Liu; Eun-Rhan Woo; Dong Gun Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-14
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  15     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-03     Revised Date:  2010-12-15    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3507-16     Citation Subset:  IM    
Affiliation:
School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Daegu 702-701, Korea. hwangb1@knu.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemistry,  isolation & purification,  pharmacology*
Candida albicans / drug effects
Cell Membrane / drug effects
Erythrocytes / drug effects,  microbiology
Furans / isolation & purification,  pharmacology*
Humans
Lignans / isolation & purification,  pharmacology*
Mycoses / drug therapy*
Plants, Medicinal
Sambucus / chemistry*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Furans; 0/Lignans; 487-36-5/pinoresinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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