Document Detail

Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective.
MedLine Citation:
PMID:  23126319     Owner:  NLM     Status:  MEDLINE    
Invasive fungal infections, although relatively rare, are life-threatening diseases in premature infants and immunocompromised children. While many advances have been made in antifungal therapeutics in the last two decades, knowledge of the pharmacokinetics and pharmacodynamics of antifungal agents for infants and children remains incomplete. This review summarizes the pharmacology and clinical utility of currently available antifungal agents and discusses the opportunities and challenges for future research.
Jodi M Lestner; P Brian Smith; Michael Cohen-Wolkowiez; Daniel K Benjamin; William W Hope
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2014-01-17     Revised Date:  2014-06-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1381-95     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Antifungal Agents / therapeutic use*
Child, Preschool
Immunocompromised Host / drug effects
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy
Mycoses / drug therapy*
Grant Support
CS/08/08/10//Department of Health
Reg. No./Substance:
0/Antifungal Agents

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