Document Detail

Antifilarial activity in vitro of polycarpol and 3-O-acetyl aleuritolic acid from cameroonian medicinal plants against Onchocerca gutturosa.
MedLine Citation:
PMID:  16644535     Owner:  NLM     Status:  MEDLINE    
Previous results have revealed the antifilarial activities of crude extracts and pure compounds from some Cameroonian medicinal plants against Onchocerca volvulus and Onchocerca gutturosa. In our efforts to find new filaricidal agents against adult male O. gutturosa worms, we have isolated and screened three compounds: polycarpol and polyveoline from Polyalthia suaveolens (Annonaceae) and 3-O-acetyl aleuritolic acid from Discoglypremna caloneura (Euphorbiaceae). Only polycarpol and 3-O-acetyl aleuritolic acid exhibited significant inhibitory activities on the vitality of adult male worms of O. gutturosa using Amocarzine as positive control compound. The motility reduction values were 28.6 and 57.1%, and the inhibition of MTT reduction values 80.0 and 64.8% respectively.
B Nyasse; I Ngantchou; J-J Nono; B Schneider
Related Documents :
11000025 - Four cycloartane triterpenoids and six related saponins from passiflora edulis.
15279975 - Chemical constituents of leaves and stem bark of plumeria obtusa.
16141585 - New oleanene glycosides from the leaves of acanthopanax japonicus.
20506045 - Sweetgum (liquidambar styraciflua l.): extraction of shikimic acid coupled to dilute ac...
19782765 - Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance...
18052835 - Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product research     Volume:  20     ISSN:  1478-6419     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Department of Organic Chemistry, Laboratory of Bio-organic and Medicinal Chemistry, Faculty of Sciences, University of Yaoundé I, Box 812 Yaoundé, Cameroon.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anthelmintics / chemistry,  isolation & purification*,  pharmacology*
Euphorbiaceae / chemistry
Molecular Structure
Onchocerca / drug effects*
Palmitic Acids / chemistry,  isolation & purification,  pharmacology*
Plant Extracts / chemistry,  pharmacology
Plants, Medicinal / chemistry*
Polyalthia / chemistry
Polycyclic Hydrocarbons, Aromatic / chemistry,  isolation & purification,  pharmacology*
Reg. No./Substance:
0/3-O-acetyl aleuritolic acid; 0/Anthelmintics; 0/Palmitic Acids; 0/Plant Extracts; 0/Polycyclic Hydrocarbons, Aromatic; 0/polycarpol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A new steroidal saponin from Agave shrevei.
Next Document:  Philinopsides E and F, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadran...