Document Detail


Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells.
MedLine Citation:
PMID:  18704328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antifibrotic effect of twelve diterpenes (1-12) from the 90% methanolic fraction of Biota orientalis leaves was evaluated employing HSC-T6 cells by assessing cell proliferation and morphological change. Among these diterpenes, totarol (8) and isopimara-8(14),15-dien-19-oic acid (9) dramatically reduced cell proliferation in dose-and time-dependent manner. Furthermore, treatment with these compounds resulted in the different pattern of morphological changes of HSC-T6 cells. Taken together, antiproliferative activity of diterpenes from B. orientalis might suggest therapeutic potentials against liver fibrosis.
Authors:
Mi Kyeong Lee; Hyekyung Yang; Jeong Seon Yoon; Eun Ju Jeong; Do Yoon Kim; Na Ry Ha; Sang Hyun Sung; Young Choong Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-14
Journal Detail:
Title:  Archives of pharmacal research     Volume:  31     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  866-71     Citation Subset:  IM    
Affiliation:
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Proliferation / drug effects
Cupressaceae / chemistry*
Diterpenes / isolation & purification,  pharmacology*
Dose-Response Relationship, Drug
L-Lactate Dehydrogenase / metabolism
Liver Cirrhosis / pathology,  prevention & control*
Plant Leaves / chemistry*
Rats
Chemical
Reg. No./Substance:
0/Diterpenes; EC 1.1.1.27/L-Lactate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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