| Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells. | |
| | |
MedLine Citation:
|
PMID: 18704328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antifibrotic effect of twelve diterpenes (1-12) from the 90% methanolic fraction of Biota orientalis leaves was evaluated employing HSC-T6 cells by assessing cell proliferation and morphological change. Among these diterpenes, totarol (8) and isopimara-8(14),15-dien-19-oic acid (9) dramatically reduced cell proliferation in dose-and time-dependent manner. Furthermore, treatment with these compounds resulted in the different pattern of morphological changes of HSC-T6 cells. Taken together, antiproliferative activity of diterpenes from B. orientalis might suggest therapeutic potentials against liver fibrosis. |
| | |
Authors:
|
Mi Kyeong Lee; Hyekyung Yang; Jeong Seon Yoon; Eun Ju Jeong; Do Yoon Kim; Na Ry Ha; Sang Hyun Sung; Young Choong Kim |
Related Documents
:
|
6832348 - Urinary polyamine excretion as related to cell death and cell proliferation induced by ... 1530788 - Hepatocyte growth factor/hepatopoietin a is expressed in fat-storing cells from rat liv... 10369408 - Sex hormone binding globulin expression and colocalization with estrogen receptor in th... 2891538 - Differentiation of b cell progenitors in vitro: generation of surface igm+ b cells, inc... 10958988 - Cell cycle g2 arrest induced by hiv-1 vpr in fission yeast (schizosaccharomyces pombe) ... 21200138 - The importance of being in the right place at the right time: overexpression of cdk2 an... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-14 |
Journal Detail:
|
Title: Archives of pharmacal research Volume: 31 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-08-15 Completed Date: 2008-09-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 866-71 Citation Subset: IM |
Affiliation:
|
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Line Cell Proliferation / drug effects Cupressaceae / chemistry* Diterpenes / isolation & purification, pharmacology* Dose-Response Relationship, Drug L-Lactate Dehydrogenase / metabolism Liver Cirrhosis / pathology, prevention & control* Plant Leaves / chemistry* Rats |
| Chemical | |
Reg. No./Substance:
|
0/Diterpenes; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension i...
Next Document: Cytoprotective roles of senescence marker protein 30 against intracellular calcium elevation and oxi...