| Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. | |
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MedLine Citation:
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PMID: 21082271 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The CHCl(3) fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines. Activity-guided fractionation of the CHCl(3) fraction of C. monnieri led to the isolation of ten coumarins: osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10). Of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner. In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells. |
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Authors:
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Eunjin Shin; Chul Lee; Sang Hyun Sung; Young Choong Kim; Bang Yeon Hwang; Mi Kyeong Lee |
Publication Detail:
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Type: Journal Article Date: 2010-11-17 |
Journal Detail:
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Title: Journal of natural medicines Volume: 65 ISSN: 1861-0293 ISO Abbreviation: J Nat Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101518405 Medline TA: J Nat Med Country: Japan |
Other Details:
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Languages: eng Pagination: 370-4 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Chungbuk National University, 410 Seongbong-ro, Heungduk-gu, Cheongju, 361-763, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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