Document Detail

Antifibrinolytic therapy in patients with aneurysmal subarachnoid haemorrhage.
MedLine Citation:
PMID:  3267328     Owner:  NLM     Status:  MEDLINE    
In a prospective consecutive non-randomised study including 1076 patients with ruptured intracranial aneurysms 205 patients received epsilon aminocraproic acid (EACA) and 871 did not. No significant differences between the two groups concerning clinical condition on admission, sex, age, localisation and size of the aneurysms were seen. No cases of rebleeding (RB) were observed within the first 4 days in the EACA treated patients, but within the first 48 hours, which is the optimal period recommended for operation of patients in good clinical condition, this difference of the rates of RB between EACA treated and not treated patients is not significant. A significantly lower rate of RB was observed in the EACA group within the first 2 weeks, but no significant differences in morbidity and mortality were found at the 2-year follow-up examination.
J Rosenørn; V Eskesen; J O Espersen; J Haase; K Schmidt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of neurosurgery     Volume:  2     ISSN:  0268-8697     ISO Abbreviation:  Br J Neurosurg     Publication Date:  1988  
Date Detail:
Created Date:  1989-11-20     Completed Date:  1989-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800054     Medline TA:  Br J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  IM    
Department of Neurosurgery, Aalborg Hospital, Denmark.
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MeSH Terms
Antifibrinolytic Agents / therapeutic use*
Intracranial Aneurysm / complications*
Middle Aged
Prospective Studies
Rupture, Spontaneous
Subarachnoid Hemorrhage / drug therapy*,  etiology
Reg. No./Substance:
0/Antifibrinolytic Agents

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