Document Detail

Antifibrinolytic agents in subarachnoid haemorrhage.
MedLine Citation:
PMID:  3546604     Owner:  NLM     Status:  MEDLINE    
For many years clinicians have used antifibrinolytic agents to try to reduce rebleeding after subarachnoid haemorrhage. Early studies of their effectiveness produced conflicting results. This paper re-evaluates the available trials and considers benefits in the light of potential complications. Present evidence conclusively demonstrates that epsilon-aminocaproic acid and tranexamic acid administered in standard dosage, reduce the risk of rebleeding but, as a result of an increased incidence of ischaemic complications, do not benefit patients' outcome.
K W Lindsay
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neurology     Volume:  234     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-14     Completed Date:  1987-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
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MeSH Terms
Antifibrinolytic Agents / therapeutic use*
Subarachnoid Hemorrhage / drug therapy*
Reg. No./Substance:
0/Antifibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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