| Antifibrillatory, cardiovascular and toxic effects of sparteine, butylsparteine and pentylsparteine. | |
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MedLine Citation:
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PMID: 7193016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The negative bathmo- ino and chronotropic effects of sparteine, butylsparteine and pentylsparteine were quantitatively determined in isolated rat atria. The antifibrillatory potency was studied in rats (aconitine arrhythmia), guinea pigs (digoxin arrhythmia) and in cats (spontaneous arrhythmia). In order to appraise the cardiovascular compatibility of these drugs, additional circulatory effects were studied in rats and cats. Acute toxicity following intravenous, intraperitoneal and oral administration was assessed in male and female mice. Pentylsparteine was more potent than sparteine and had a better therapeutic index. |
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Authors:
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G Zetler; O Strubelt |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 30 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1980 |
Date Detail:
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Created Date: 1981-03-17 Completed Date: 1981-03-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1497-502 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents* Arrhythmias, Cardiac / chemically induced Cardiovascular Agents* Female Guinea Pigs Heart / drug effects Hemodynamics / drug effects Lethal Dose 50 Male Mice Muscle Contraction / drug effects Rats Sparteine / analogs & derivatives*, pharmacology*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Cardiovascular Agents; 52670-57-2/17-butylsparteine; 52670-65-2/17-pentylsparteine; 90-39-1/Sparteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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