| Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers. | |
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MedLine Citation:
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PMID: 3199836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antifertility activity of oleanolic acid (C30H48O3), isolated from the flowers of Eugenia jambolana, was evaluated in male albino rats. The administration of the compound for 60 days decreased the fertilizing capacity of the animals without any significant changes in body weight or reproductive organ weights. The compound produced arrest of spermatogenesis but did not cause any abnormality to spermatogenic cells, Leydig interstitial cells and Sertoli cells. Oleanolic acid may prove to be a promising antifertility agent devoid of undesirable side effects. |
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Authors:
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M Rajasekaran; J S Bapna; S Lakshmanan; A G Ramachandran Nair; A J Veliath; M Panchanadam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 24 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1989-01-26 Completed Date: 1989-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 115-21 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Pondicherry, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contraceptive Agents, Male* Male Oleanolic Acid / isolation & purification, pharmacology* Plants, Medicinal* Rats Rats, Inbred Strains Sapogenins / pharmacology* Spermatogenesis / drug effects Testis / anatomy & histology, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Contraceptive Agents, Male; 0/Sapogenins; 508-02-1/Oleanolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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