Document Detail

Antifertility effect in male rats of oleanolic acid, a triterpene from Eugenia jambolana flowers.
MedLine Citation:
PMID:  3199836     Owner:  NLM     Status:  MEDLINE    
The antifertility activity of oleanolic acid (C30H48O3), isolated from the flowers of Eugenia jambolana, was evaluated in male albino rats. The administration of the compound for 60 days decreased the fertilizing capacity of the animals without any significant changes in body weight or reproductive organ weights. The compound produced arrest of spermatogenesis but did not cause any abnormality to spermatogenic cells, Leydig interstitial cells and Sertoli cells. Oleanolic acid may prove to be a promising antifertility agent devoid of undesirable side effects.
M Rajasekaran; J S Bapna; S Lakshmanan; A G Ramachandran Nair; A J Veliath; M Panchanadam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  24     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  IM    
Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Pondicherry, India.
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MeSH Terms
Contraceptive Agents, Male*
Oleanolic Acid / isolation & purification,  pharmacology*
Plants, Medicinal*
Rats, Inbred Strains
Sapogenins / pharmacology*
Spermatogenesis / drug effects
Testis / anatomy & histology,  drug effects
Reg. No./Substance:
0/Contraceptive Agents, Male; 0/Sapogenins; 508-02-1/Oleanolic Acid

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